Department of Chemistry, College of Sciences, Northeastern University, Shenyang, 110819, China; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
Anal Chim Acta. 2023 Sep 15;1274:341496. doi: 10.1016/j.aca.2023.341496. Epub 2023 Jun 15.
Ionic liquids (ILs), which are salts in a molten state below 100 °C, have become a hot topic of research in various fields because of their negligible vapour pressure, high thermal stability, and tunable viscosity. Chiral ionic liquids (CILs) can be applied in chromatography and capillary electrophoresis fields to improve the performance of enantiomeric separation, such as chiral stationary phases (CSPs) and mobile phase additives in high-performance liquid chromatography (HPLC); CSPs in gas chromatography (GC); and background electrolyte additives (BGE), chiral ligands and chiral selectors (CSs) in capillary electrophoresis (CE). This review focuses on the applications of CILs in HPLC and CE for the separation of enantiomers in the past five years. The mechanism for separating enantiomers was explained, and the prospect of the application of CILs in chiral liquid chromatography (LC) and CE analysis was also discussed.
离子液体（ILs）在 100°C 以下处于熔融状态，因其蒸汽压可忽略不计、热稳定性高、粘度可调而成为各个领域的热门研究课题。手性离子液体（CILs）可应用于色谱法和毛细管电泳领域，以改善对映体分离的性能，例如高效液相色谱（HPLC）中的手性固定相（CSP）和流动相添加剂；气相色谱（GC）中的 CSP；以及毛细管电泳（CE）中的背景电解质添加剂（BGE）、手性配体和手性选择器（CSs）。本文综述了过去五年中 CILs 在 HPLC 和 CE 中用于分离对映体的应用。解释了分离对映体的机制，并讨论了 CILs 在手性液相色谱（LC）和 CE 分析中的应用前景。
