Kartje-Tillotson G, Neafsey E J, Castro A J
J Comp Neurol. 1986 Aug 8;250(2):206-14. doi: 10.1002/cne.902500207.
Autoradiographic and axonal degeneration staining techniques were combined in individual animals to study the distribution of corticopontine fibers. In normal animals, forelimb and hindlimb motor cortical projections terminated somatotopically within the ipsilateral pontine nuclei. Sparse crossed projections also displayed a somatotopic pattern. After unilateral sensorimotor cortical lesions in newborn rats, an increase in the crossed corticopontine fibers arising from the opposite unablated motor cortex was observed at maturity. These fibers distributed in a topographic pattern similar to the normal ipsilateral corticopontine pattern; forelimb motor cortical projections terminated rostral to hindlimb motor cortical fibers. The specific distribution of the anomalous fibers suggests that they constitute a functional pathway.
将放射自显影和轴突退变染色技术应用于个体动物，以研究皮质脑桥纤维的分布。在正常动物中，前肢和后肢运动皮质投射在同侧脑桥核内按躯体定位终止。稀疏的交叉投射也呈现出躯体定位模式。新生大鼠单侧感觉运动皮质损伤后，在成熟时观察到来自对侧未受损运动皮质的交叉皮质脑桥纤维增加。这些纤维以与正常同侧皮质脑桥模式相似的拓扑模式分布；前肢运动皮质投射终止于后肢运动皮质纤维的前方。异常纤维的特定分布表明它们构成了一条功能通路。
