三种队列研究中按部位分层的循环激素与胃癌风险
Circulating hormones and risk of gastric cancer by subsite in three cohort studies.
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St. Mary's Campus, Norfolk Place, London, W2 1PG, UK.
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
出版信息
Gastric Cancer. 2023 Nov;26(6):969-987. doi: 10.1007/s10120-023-01414-0. Epub 2023 Jul 16.
BACKGROUND
Obesity has been positively associated with gastric cancer. Excess fat impacts hormones, which have been implicated in carcinogenesis. We investigated obesity-related hormones and cardia gastric cancer (CGC) and non-cardia gastric cancer (NCGC) risk.
METHODS
Nested case-control studies were conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (61 CGCs, and 172 NCGCs and matched controls) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) study (100 CGCs and 65 NCGCs and matched controls); serum hormones were measured. In UK-Biobank (n = 458,713), we included 137 CGCs and 92 NCGCs. Sex-specific analyses were conducted. For EPIC and ATBC, odds ratios (ORs), and for UK-Biobank hazard ratios (HRs), were estimated using conditional logistic regression and Cox regression, respectively.
RESULTS
Insulin-like growth-factor-1 was positively associated with CGC and NCGC in EPIC men (OR 1.94, 95% CI 1.03-3.63; OR 1.63, 95% CI 1.05-2.53, respectively), with similar findings for CGC in UK-Biobank women (HR 1.76, 95% CI 1.08-2.88). Leptin in EPIC men and C-peptide in EPIC women were positively associated with NCGC (OR 2.72, 95% CI 1.01-7.34 and OR 2.17, 95% CI 1.19-3.97, respectively). Sex hormone-binding globulin was positively associated with CGC in UK-Biobank men (HR 1.29, 95% CI 1.02-1.64). Conversely, ghrelin was inversely associated with NCGC among EPIC and ATBC men (OR 0.53, 95% CI 0.34-0.84; OR 0.22, 95% CI 0.10-0.50, respectively). In addition, dehydroepiandrosterone was inversely associated with CGC in EPIC and ATBC men combined.
CONCLUSIONS
Some obesity-related hormones influence CGC and NCGC risk.
背景
肥胖与胃癌呈正相关。多余的脂肪会影响激素，而这些激素与致癌作用有关。我们研究了与肥胖相关的激素与贲门胃癌（CGC）和非贲门胃癌（NCGC）的风险。
方法
在欧洲癌症前瞻性调查与营养研究（EPIC）队列（61 例 CGC，172 例 NCGC 和匹配对照）和α-生育酚，β-胡萝卜素癌症预防（ATBC）研究（100 例 CGC，65 例 NCGC 和匹配对照）中进行了嵌套病例对照研究；测量了血清激素。在英国生物银行（n=458713）中，我们纳入了 137 例 CGC 和 92 例 NCGC。进行了性别特异性分析。对于 EPIC 和 ATBC，使用条件逻辑回归和 Cox 回归分别估计比值比（ORs），对于 UK-Biobank，使用风险比（HRs）进行估计。
结果
胰岛素样生长因子-1（IGF-1）与 EPIC 男性的 CGC 和 NCGC 呈正相关（OR 1.94，95%CI 1.03-3.63；OR 1.63，95%CI 1.05-2.53），在 UK-Biobank 女性中也有类似的 CGC 发现（HR 1.76，95%CI 1.08-2.88）。EPIC 男性的瘦素和 EPIC 女性的 C 肽与 NCGC 呈正相关（OR 2.72，95%CI 1.01-7.34 和 OR 2.17，95%CI 1.19-3.97）。在 UK-Biobank 男性中，性激素结合球蛋白与 CGC 呈正相关（HR 1.29，95%CI 1.02-1.64）。相反，ghrelin 与 EPIC 和 ATBC 男性的 NCGC 呈负相关（OR 0.53，95%CI 0.34-0.84；OR 0.22，95%CI 0.10-0.50）。此外，脱氢表雄酮与 EPIC 和 ATBC 男性的 CGC 呈负相关。
结论
一些与肥胖相关的激素影响 CGC 和 NCGC 的风险。
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