Hermans Michel He
Hermans Medical Consulting Hoorn, The Netherlands.
Int J Burns Trauma. 2023 Jun 15;13(3):136-141. eCollection 2023.
Topical desiccation agent (TDA) is an acidic species in a gel with a potent hygroscopic action. When in contact with (water in) biofilm and necrosis, rapid desiccation occurs, with the dehydrated tissues typically sloughing off in 1-3 days. This allows for quick granulation tissue formation which is an essential step for healing by secondary intention or as wound bed preparation for grafting.
A series of nine non-healing, post-trauma lesions on the lower leg were treated with TDA, followed by treatment of the lesion with vaseline gauze.
The average age of the patients was 77.0 years and the lesions had been in existence for 5.6 months on average. The average size of the lesion was 15.9 cm. Complete granulation of all lesions was reached in an average of 34.1 days while the time to complete reepithelialization averaged, 69.8 days (data from one outlier removed). There were no adverse events.
These data suggest TDA treatment is an effective and efficient way to debride lesions, and to prepare them for healing by secondary intention or for grafting.
局部干燥剂（TDA）是一种凝胶状的酸性物质，具有强大的吸湿作用。当与生物膜和坏死组织中的（水分）接触时，会迅速发生干燥，脱水组织通常在1 - 3天内脱落。这有利于快速形成肉芽组织，这是二期愈合或作为移植创面床准备的关键步骤。
对小腿上一系列9处创伤后不愈合的损伤使用TDA进行治疗，随后用凡士林纱布处理损伤部位。
患者的平均年龄为77.0岁，损伤平均已存在5.6个月。损伤的平均大小为15.9平方厘米。所有损伤平均在34.1天达到完全肉芽形成，而完全重新上皮化的时间平均为69.8天（去除一个异常值的数据）。未发生不良事件。
这些数据表明，TDA治疗是一种有效且高效的清创方法，可为二期愈合或移植准备创面。
