地塞米松给药对雌性白化大鼠性腺-生育功能的影响。
Effect of dexamethasone administration on gonadal-fertility functions in female albino rats.
机构信息
Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan.
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Taibah University, AL-Madinah, Saudi Arabia.
出版信息
Pan Afr Med J. 2023 Apr 5;44:160. doi: 10.11604/pamj.2023.44.160.36748. eCollection 2023.
INTRODUCTION
dexamethasone is misused for skin whitening with broad effects on steroidogenesis and ovarian functions. Here in we investigated the impact of dexamethasone administration on gonadotropin Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), prolactin, and ovarian tissues in albino rats.
METHODS
in the experimental study, 36 female albino rats weighting (140-162 g) were divided into three groups: control, normal dose received dexamethasone (8.3 μg/kg/day) and high dose (24.9 μg/kg/day), for 30 and 60 days. follicle stimulating hormone, luteinizing hormone, and prolactin (PRL) were measured. Histological ovarian sections were examined.
RESULTS
luteinizing hormone, follicle stimulating hormone and prolactin significantly increased (p-value < 0.05) following dexamethasone treatment compared to control. The ovary sections showed degenerative tissue with necrosis of the Graafian follicles, stromal fibrosis, and vacuolation of the interstitial cells.
CONCLUSION
the study concludes that dexamethasone administration has a potentially adverse effect on gonadotropin, prolactin, and ovarian follicle cells in female albino rats.
简介
地塞米松被滥用于皮肤美白，对类固醇生成和卵巢功能有广泛影响。在这里，我们研究了地塞米松给药对促性腺激素黄体生成素 (LH) 和卵泡刺激素 (FSH)、催乳素以及白化大鼠卵巢组织的影响。
方法
在这项实验研究中，将 36 只体重为 (140-162 g) 的雌性白化大鼠分为三组：对照组、接受正常剂量地塞米松 (8.3 μg/kg/天) 的正常剂量组和接受高剂量地塞米松 (24.9 μg/kg/天) 的高剂量组，共 30 天和 60 天。测量卵泡刺激素、黄体生成素和催乳素 (PRL)。检查卵巢组织学切片。
结果
与对照组相比，地塞米松治疗后黄体生成素、卵泡刺激素和催乳素显著增加 (p 值 < 0.05)。卵巢切片显示退化组织伴有格拉夫卵泡坏死、基质纤维化和间质细胞空泡化。
结论
该研究得出结论，地塞米松给药对雌性白化大鼠的促性腺激素、催乳素和卵巢卵泡细胞有潜在的不良影响。
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