Tamura Hiroshi
Department of Pediatrics, Kumamoto University, Kumamoto 8608556, Japan.
World J Methodol. 2023 Jun 20;13(3):67-78. doi: 10.5662/wjm.v13.i3.67.
The relationship between IgA nephropathy (IgAN) and Crohn's disease was reported. IgAN is the most common primary glomerulonephritis and one of the leading causes of chronic kidney disease and end-stage renal failure, and up to 50% of cases progressed to end-stage renal disease within 25 years after IgAN diagnosis. However, specific and effective therapeutic strategies are still lacking. In this review, we discuss the possibility of the mechanism involved in IgAN associated with Crohn's disease based on the findings of basic and clinical studies. Although the etiology of IgAN associated with Crohn's disease is not permanent and various factors are thought to be involved, the stabilization of the disease condition of Crohn's disease is believed to help treat IgAN.
有报道称了IgA肾病（IgAN）与克罗恩病之间的关系。IgA肾病是最常见的原发性肾小球肾炎，也是慢性肾脏病和终末期肾衰竭的主要病因之一，高达50%的病例在IgA肾病确诊后25年内进展为终末期肾病。然而，仍然缺乏特异性和有效的治疗策略。在这篇综述中，我们基于基础和临床研究的结果，探讨了与克罗恩病相关的IgA肾病所涉及机制的可能性。尽管与克罗恩病相关的IgA肾病的病因并不明确，且认为涉及多种因素，但据信克罗恩病病情的稳定有助于治疗IgA肾病。
