1例发生于乳腺癌化疗后的母细胞性浆细胞样树突状细胞肿瘤罕见病例。
A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Occurred in Postchemotherapy of Breast Cancer.
作者信息
Tong Jiankun, Aksenov Sergei, Siegel Beth M, Wei Lihong, Rodgers William H
机构信息
Department of Pathology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USA.
Department of Surgery, Section of Breast Surgery, New York Presbyterian Queens, 58-04 Main Street, Flushing, NY 11355, USA.
出版信息
Case Rep Hematol. 2023 Jul 6;2023:7573037. doi: 10.1155/2023/7573037. eCollection 2023.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy that arises from plasmacytoid dendritic cells. BPDCN typically presents with skin lesions and may involve peripheral blood, bone marrow, lymph nodes, or extranodal sites. It usually arises de novo, and some BPDCN cases are associated with or develop into myeloid neoplasms. Here, we report a case of a 57-year-old female presenting with cervical lymphadenopathy and skin rashes during the COVID-19 pandemic in 2021 following multiple types of postmastectomy therapy for breast cancer. The patient was ultimately diagnosed with BPCDN by lymph node biopsy. To the best of our knowledge, this is the first case report of BPDCN occurring postchemotherapy of breast cancer.
母细胞性浆细胞样树突状细胞肿瘤（BPDCN）是一种罕见且侵袭性很强的血液系统恶性肿瘤，起源于浆细胞样树突状细胞。BPDCN通常表现为皮肤病变，可能累及外周血、骨髓、淋巴结或结外部位。它通常是原发性的，一些BPDCN病例与髓系肿瘤相关或发展为髓系肿瘤。在此，我们报告一例57岁女性病例，该患者在2021年新冠疫情期间，在接受多种乳腺癌乳房切除术后治疗后出现颈部淋巴结肿大和皮疹。患者最终通过淋巴结活检被诊断为BPCDN。据我们所知，这是乳腺癌化疗后发生BPDCN的首例病例报告。
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