Kolerova Anastasiia, Sergeeva Irina, Krinitsyna Julia, Pronkina Natalia, Sizikova Svetlana, Filimonov Pavel, Kryuchkova Irina
Center of Postgraduate Medical Education, Novosibirsk National Research State University, Novosibirsk, Russian Federation.
Novosibirsk Research Institute of Fundamental and Clinical Immunology, Novosibirsk, Russian Federation.
Indian J Dermatol. 2020 May-Jun;65(3):217-221. doi: 10.4103/ijd.IJD_235_18.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. The patient was put on acute lymphoblastic leukemia-like chemotherapy and achieved complete remission in November 2016, the eruption regressed. In January 2017, allogeneic bone marrow transplantation from matched sibling was performed. Since May 2017, the cutaneous relapse with loss of CD56 expression has developed. This clinical case demonstrates the importance of laboratory tests. Histological examination helps to clarify a diagnosis of cutaneous lymphoma; however, a specific type of lymphoma needs immunohistochemical analysis. In our case, BPDCN at the initial stage presented like a systemic vasculitis.
母细胞性浆细胞样树突状细胞肿瘤（BPDCN）是一种皮肤受累频率较高的恶性肿瘤。一名39岁的白种女性在2016年7月用抗生素治疗衣原体感染期间出现乏力、肌痛和皮疹。根据临床表现、实验室检查以及皮肤和骨髓活检的组织学检查，诊断为BPDCN，累及皮肤、骨髓和中枢神经系统。该患者接受了急性淋巴细胞白血病样化疗，并于2016年11月实现完全缓解，皮疹消退。2017年1月，进行了来自匹配同胞的异基因骨髓移植。自2017年5月以来，出现了伴有CD56表达缺失的皮肤复发。该临床病例证明了实验室检查的重要性。组织学检查有助于明确皮肤淋巴瘤的诊断；然而，特定类型的淋巴瘤需要免疫组化分析。在我们的病例中，初期的BPDCN表现类似系统性血管炎。
