Verma Shikha, Kumari Sakshi, Chhangte Mary Zothanpuii
Department of Dermatology and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.
Indian J Sex Transm Dis AIDS. 2023 Jan-Jun;44(1):74-76. doi: 10.4103/ijstd.ijstd_103_22. Epub 2023 Jun 6.
Malignant syphilis (lues maligna) is a rare form of secondary syphilis, first described by Bazin in 1859, frequently associated with HIV infection. The resurgence of syphilis in the recent times has been attributed to rise in HIV infection. Malignant syphilis is characterized by the presence of pleomorphic multiple round-to-oval papules, papulopustules, or nodules with ulceration, without central clearing, and occasionally exhibit a lamellate brown to black rupioid crust with prodromal symptoms. We herein report a case of early malignant syphilis in a young immunocompromised patient who was HIV positive and noncompliant to antiretroviral therapy, from Northeast India. The HIV/AIDS epidemic is rising at an alarming rate in this part of the country which has thus led to an increase in the number of other sexually transmitted infections.
恶性梅毒（lues maligna）是二期梅毒的一种罕见形式，于1859年由巴赞首次描述，常与HIV感染相关。近年来梅毒的再度流行归因于HIV感染率的上升。恶性梅毒的特征是存在多形性的多个圆形至椭圆形丘疹、丘脓疱或结节，并伴有溃疡，无中央消退，偶尔可见有前驱症状的层状棕色至黑色蛎壳样痂皮。我们在此报告一例来自印度东北部的年轻免疫功能低下患者的早期恶性梅毒病例，该患者HIV阳性且未坚持抗逆转录病毒治疗。该国这一地区的HIV/AIDS疫情正以惊人的速度上升，这导致了其他性传播感染病例数量的增加。
