Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000, Cheras, Kuala Lumpur, Malaysia.
Centre for Tissue Engineering & Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000, Cheras, Kuala Lumpur, Malaysia.
Mediators Inflamm. 2023 Jul 7;2023:9715114. doi: 10.1155/2023/9715114. eCollection 2023.
Coronary artery disease (CAD) is a caused by atherosclerotic plaque buildup in the coronary arteries that supply blood and oxygen to the heart. Matrix metalloproteinase (MMP) is a family of zinc-dependent endopeptidase that is involved in various stages of atherosclerosis as demonstrated in and studies. MMP-2 is associated with both stable and unstable atherosclerotic plaque formation. The current review aimed to identify the role of MMP-2 in atherosclerosis development among CAD patients. Literature search was conducted through four online databases and only studies that were published from 2018 until February 2023 were included. The risk of bias was assessed by using the Newcastle-Ottawa Scale. A total of 10,622 articles were initially identified, and only eight studies that fulfilled the selection criteria were included in this review. The results showed that MMP-2 levels and activity were higher in patients with unstable CAD than those with stable CAD and healthy subjects. There was a significant association between MMP-2 levels and cardiovascular disease with MMP-14 levels, which is a pro-MMP-2 activator. In addition, two single nucleotide polymorphisms of the MMP-2 gene (rs243865 and rs243866) were significantly associated with the development of atherosclerosis. In conclusion, MMP-2 plays a crucial role in the development of atherosclerosis among patients with CAD and could be a potential target for CAD therapy.
冠状动脉疾病 (CAD) 是由于供应心脏血液和氧气的冠状动脉中动脉粥样硬化斑块的积累而引起的。基质金属蛋白酶 (MMP) 是一种锌依赖性内肽酶家族，在动脉粥样硬化的各个阶段都有涉及，如 和 研究所示。MMP-2 与稳定和不稳定的动脉粥样硬化斑块形成都有关。本综述旨在确定 MMP-2 在 CAD 患者动脉粥样硬化发展中的作用。通过四个在线数据库进行文献检索，仅纳入 2018 年 2 月至 2023 年期间发表的研究。使用纽卡斯尔-渥太华量表评估偏倚风险。最初确定了 10622 篇文章，只有符合选择标准的八项研究被纳入本综述。结果表明，不稳定 CAD 患者的 MMP-2 水平和活性高于稳定 CAD 患者和健康受试者。MMP-2 水平与心血管疾病与 MMP-14 水平之间存在显著关联，MMP-14 水平是一种促 MMP-2 激活剂。此外，MMP-2 基因的两个单核苷酸多态性 (rs243865 和 rs243866) 与动脉粥样硬化的发展显著相关。总之，MMP-2 在 CAD 患者的动脉粥样硬化发展中起着至关重要的作用，可能成为 CAD 治疗的潜在靶点。
