[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].

Clove oil injection in the anterior chamber of the rabbit eye produces an uveitis and a disruption of the blood-ocular barrier which can be evaluated by the leakage of 125I-radiolabelled rabbit serum albumin (RSA) administered intravenously. In the normal rabbit eye the amount of RSA in the aqueous humor is quite small. The disruption of the blood-ocular barrier by clove oil injection increases the RSA level in the anterior chamber of the eye. Topically applied chromocarb diethylamine reduces significantly the disruption of the blood-ocular barrier in the inflamed eye. Despite of its lack of anti-inflammatory activity, this compound, as a 10% eye-drop formulation, was shown nearly as effective as prednisolone 0.1%, in the corneal edema and the disruption of the blood-ocular barrier.