通过串联钯/降冰片烯催化的脱羰基反应和双C-H活化序列构建吲哚稠合的七元和八元氮杂环。
Construction of Indole-Fused Seven- and Eight-Membered Azaheterocycles via a Tandem Pd/NBE-Catalyzed Decarbonylation and Dual C-H Activation Sequence.
作者信息
Liu Yu-Wen, Wang Meng-Meng, Zhang Yun-Qian, Xu Hui, Dai Hui-Xiong
机构信息
CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
出版信息
Org Lett. 2023 Jul 28;25(29):5406-5410. doi: 10.1021/acs.orglett.3c01579. Epub 2023 Jul 17.
Herein, we report the transformation of aromatic acids to indole-fused seven- and eight-membered azaheterocycles. Two C-C bonds are formed via the cleavage of one C-C bond and two C-H bonds. The incorporation of indole moieties into bioactive pharmaceuticals and natural products to construct a medium-sized polyfused heterocycle demonstrates the synthetic utility of the protocol.
在此，我们报道了将芳香酸转化为吲哚稠合的七元及八元氮杂环。通过一个碳 - 碳键和两个碳 - 氢键的断裂形成两个碳 - 碳键。将吲哚部分引入生物活性药物和天然产物中以构建中等大小的多稠合杂环，证明了该方法的合成实用性。
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