Colon cancer in the Cronkhite-Canada syndrome.

A patient with Cronkhite-Canada syndrome had multiple juvenile colonic polyps with hyperplastic, adenomatous, and mixed villous and adenomatous changes. A Dukes B mucus-secreting adenocarcinoma of the cecum was also present. Currently considered a benign disease, the Cronkhite-Canada syndrome may be a premalignant disorder, as our patient's course suggests. We review the literature in this regard.