Coles G C
J Helminthol. 1986 Sep;60(3):210-2. doi: 10.1017/s0022149x00026110.
Triclabendazole was tested in vitro and in vivo against a range of helminths. Although in vitro activity was found against Hymenolepis diminuta (0.5 microgram/ml), Fasciola hepatica (2.5 micrograms/ml), Taenia crassiceps and Schistosoma mansoni (50 micrograms/ml), in vivo activity was only found against F. hepatica, a single oral dose of 40 mg/kg killing 99% of adult flukes in the rat. This spectrum of activity suggests a mechanism of action unlike that of other benzimidazole anthelmintics.
对三氯苯达唑进行了体外和体内试验，以对抗一系列蠕虫。虽然发现其体外活性针对微小膜壳绦虫（0.5微克/毫升）、肝片吸虫（2.5微克/毫升）、粗颈绦虫和曼氏血吸虫（50微克/毫升），但体内活性仅针对肝片吸虫，大鼠口服40毫克/千克的单剂量可杀死99%的成虫。这种活性谱表明其作用机制与其他苯并咪唑驱虫药不同。
