Division of Child Neurology, Department of Pediatrics, Cohen Children's Medical Center, 2001 Marcus Ave, Suite W290, New Hyde Park, NY, 11042, USA.
Curr Neurol Neurosci Rep. 2023 Sep;23(9):469-477. doi: 10.1007/s11910-023-01284-0. Epub 2023 Jul 17.
To review the relationship between sleep, neurodevelopment, and epilepsy and potential underlying physiological mechanisms.
Recent studies have advanced our understanding of the role of sleep in early brain development and epilepsy. Epileptogenesis has been proposed to occur when there is a failure of normal adaptive processes of synaptic and homeostatic plasticity. This sleep-dependent transformation may explain the cognitive impairment seen in epilepsy, especially when occurring early in life. The glymphatic system, a recently discovered waste clearance system of the central nervous system, has been described as a potential mechanism underlying the relationship between sleep and seizures and may account for the common association between sleep deprivation and increased seizure risk. Epilepsy and associated sleep disturbances can critically affect brain development and neurocognition. Here we highlight recent findings on this topic and emphasize the importance of screening for sleep concerns in people with epilepsy.
综述睡眠、神经发育和癫痫之间的关系，以及潜在的生理机制。
最近的研究加深了我们对睡眠在大脑早期发育和癫痫中的作用的理解。癫痫发生被认为是当正常的突触和体内平衡可塑性适应过程失败时发生的。这种睡眠依赖性的转变可以解释癫痫中观察到的认知障碍，尤其是在生命早期发生时。新近发现的中枢神经系统废物清除系统——糖质系统，被描述为睡眠与癫痫之间关系的潜在机制，并且可能解释了睡眠剥夺与癫痫发作风险增加之间的常见关联。癫痫和相关的睡眠障碍会严重影响大脑发育和神经认知。在这里，我们强调了这一主题的最新发现，并强调了在癫痫患者中筛查睡眠问题的重要性。
