Fertility Medical Group, Av. Brigadeiro Luiz Antônio, 4545. São Paulo - SP, Brazil. Zip: 01401-002.
Instituto Sapientiae - Centro de Estudos e Pesquisa em Reprodução Assistida Rua Vieira Maciel, 62. São Paulo - SP, Brazil. Zip: 04503-040.
JBRA Assist Reprod. 2023 Sep 12;27(3):490-495. doi: 10.5935/1518-0557.20230012.
To prove the hypothesis that beetroot, watermelon and ginger juice supplementation improves the endometrial receptivity and clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles.
This prospective randomized study enrolled 436 female patients undergoing ICSI cycles from January/2018 to June/2021, in a private university-affiliated IVF center. Female patients were randomized in a 1:3 ratio to either Control (n=109) or Supplementation Group (n=327). All patients received nutritional orientation before the beginning of the treatment. Participants in the Supplementation Group were instructed to intake a daily dose of homemade juice, prepared with fresh beetroot, watermelon and ginger, from the day of embryo transfer until the day of pregnancy test, while patients in Control Group did not follow the juice protocol. Generalized Linear Models, adjusted for potential confounders (female age, body mass index - BMI, endometrial thickness upon embryo transfer, and number of transferred embryos), followed by Bonferroni post hoc test for the comparison of means between groups, were used to investigate the impact of juice supplementation on the clinical outcomes of ICSI.
Patients and cycles characteristics were equally distributed among Supplementation and Control groups. Implantation rate (25.2% vs. 20.5%, p<0.001) and clinical pregnancy rate (41.0% vs. 22.0%, p=0.039) were significantly higher in the Supplementation compared to the Control group.
The use of beetroot, watermelon and ginger juice may be considered a promising strategy for improving clinical outcomes in assisted reproductive technology (ART), without any side effects.
验证甜菜根、西瓜和姜汁补充剂可改善子宫内膜容受性并提高卵胞浆内单精子注射（ICSI）周期临床结局的假说。
本前瞻性随机研究纳入了 2018 年 1 月至 2021 年 6 月在一家私立大学附属 IVF 中心接受 ICSI 周期的 436 名女性患者。将女性患者按照 1:3 的比例随机分为对照组（n=109）或补充组（n=327）。所有患者在开始治疗前均接受营养指导。补充组患者被要求从胚胎移植日至妊娠试验日每天摄入自制的甜菜根、西瓜和姜汁，而对照组患者则不遵循果汁方案。使用广义线性模型，根据潜在混杂因素（女性年龄、体重指数-BMI、胚胎移植时的子宫内膜厚度和移植胚胎数量）进行调整，然后进行 Bonferroni 事后检验比较组间均值，以研究果汁补充对 ICSI 临床结局的影响。
补充组和对照组的患者和周期特征分布均匀。补充组的着床率（25.2%比 20.5%，p<0.001）和临床妊娠率（41.0%比 22.0%，p=0.039）均显著高于对照组。
使用甜菜根、西瓜和姜汁可能是提高辅助生殖技术（ART）临床结局的一种有前途的策略，且无任何副作用。
