Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, India.
Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, India.
J Drug Target. 2023 Aug;31(7):725-744. doi: 10.1080/1061186X.2023.2238250. Epub 2023 Jul 19.
Alzheimer's is one of the most common neurodegenerative illnesses that affect brain cellular function. In this disease, the neurons in the brain are considered to be decaying steadily but consistently by the accumulation of amyloid mass, particularly the β-amyloids, amyloid proteins, and Tau proteins. The most responsible amyloid-proteins are amyloid-40 and amyloid-42, which have a high probability of accumulating in excess over the brain cell, interfering with normal brain cell function and triggering brain cell death. The advancement of pharmaceutical sciences leads to the development of Nanotheranostics technology, which may be used to diagnose and treat Alzheimer's. They are the colloidal nanoparticles functionalised with the therapeutic moiety as well as a diagnostic moiety. This article discusses the prognosis of Alzheimer's, various nanotheranostics approaches (nanoparticles, quantum dots, aptamers, dendrimers, etc), and their recent advancement in managing Alzheimer's. Also, various and diagnostic methodologies were discussed with respect to nanotheranostics.
阿尔茨海默病是最常见的神经退行性疾病之一，会影响大脑细胞功能。在这种疾病中，大脑中的神经元被认为是通过淀粉样物质的积累而逐渐稳定但持续地衰退，特别是β-淀粉样蛋白、淀粉样蛋白和 Tau 蛋白。最负责任的淀粉样蛋白是淀粉样蛋白 40 和淀粉样蛋白 42，它们有很高的可能性在脑细胞中过度积累，干扰正常的脑细胞功能并引发脑细胞死亡。药物科学的进步导致了纳米治疗学技术的发展，该技术可用于诊断和治疗阿尔茨海默病。它们是胶体纳米粒子，功能化有治疗部分以及诊断部分。本文讨论了阿尔茨海默病的预后、各种纳米治疗方法（纳米粒子、量子点、适体、树枝状聚合物等）以及它们在治疗阿尔茨海默病方面的最新进展。此外，还讨论了各种诊断方法与纳米治疗学的关系。
