Hepatoxicity induced by clozapine: Case report and brief review.
作者信息
Revilla-Zúñiga Joshep, Cornejo-Del Carpio Joise, Cruzado Lizardo
机构信息
Instituto Nacional de Salud Mental Honorio Delgado-Hideyo Noguchi, Lima, Peru; Universidad Peruana Cayetano Heredia, Lima, Peru.
Hospital Carlos Lanfranco La Hoz, Lima, Peru.
出版信息
Rev Colomb Psiquiatr (Engl Ed). 2023 Apr-Jun;52(2):165-170. doi: 10.1016/j.rcpeng.2021.04.005. Epub 2023 Jul 15.
INTRODUCTION
Antipsychotics are drugs that can produce transient elevations of hepatic enzymes. Clozapine is an atypical antipsychotic used in treatment-resistant schizophrenia and there is evidence that it can produce elevations of hepatic transaminases, expression of liver damage in a hepatocellular pattern.
METHODS
Case report and non-systematic review of the relevant literature.
CASE PRESENTATION
A 39-year-old woman with a diagnosis of paranoid schizophrenia attended the emergency department of a general hospital for nausea, vomiting and jaundice that appeared after the initiation of clozapine. There was no clinical improvement during hospitalisation, and death occurred after 44 days.
LITERATURE REVIEW
Clozapine can increase the liver enzyme levels transiently and asymptomatically; however, there are clinical criteria that recommend the withdrawal of the antipsychotic.
CONCLUSIONS
This is the third case reported in the literature of a fatal outcome of clozapine-induced hepatotoxicity.
Zotero 插件