School of Engineering, Apadana Institute of Higher Education, Shiraz, Iran.
Sci Rep. 2023 Jul 17;13(1):11485. doi: 10.1038/s41598-023-38662-0.
Increased energy consumption as a result of population growth and industrialization necessitates the use of renewable energy sources in the field of chemistry. Nonrenewable energy sources release not only greenhouse gases but also other hazardous pollutants that are damaging to all living things. This plainly mandates the researchers' use of a renewable energy source that is both environmentally friendly and cost-effective. This study shows that a renewable energy source (sunlight) can be used to synthesize tetrahydrobenzo[b]pyran scaffolds using the Knoevenagel-Michael cyclocondensation of aldehyde derivatives, malononitrile, and dimedone via a three-condensation domino reaction. This research establishes a new role for solar energy as a renewable energy source for the synthesis of tetrahydrobenzo[b]pyran scaffolds under catalyst-solvent-free conditions, with outstanding yields, shorter reaction time, and great atom economy. This cyclization may also be done on a gram scale with free, safe, and clean energy from concentrated solar radiation (CSR), indicating the reaction's potential for industrial applications.
由于人口增长和工业化导致能源消耗增加，因此在化学领域需要使用可再生能源。不可再生能源不仅会释放温室气体，还会释放其他有害污染物，对所有生物都有危害。这就要求研究人员使用既环保又经济实惠的可再生能源。本研究表明，可再生能源（阳光）可用于通过醛衍生物、丙二腈和二亚甲基酮的 Knoevenagel-Michael 环缩合，通过三缩合多米诺反应合成四氢苯并[b]吡喃支架。该研究在无催化剂和溶剂的条件下，以太阳能为可再生能源，合成四氢苯并[b]吡喃支架，产率高、反应时间短、原子经济性好，为太阳能作为可再生能源合成四氢苯并[b]吡喃支架的应用提供了新的范例。该环化反应也可在克级规模上进行，且使用来自集中太阳辐射（CSR）的自由、安全、清洁的能源，表明该反应具有工业化应用的潜力。
