Department of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China (mainland).
Med Sci Monit. 2023 Jul 18;29:e940134. doi: 10.12659/MSM.940134.
BACKGROUND Percutaneous vertebral augmentation is the mainstream treatment of osteoporotic vertebral compression fracture (OVCF). New vertebral compression fracture (NVCF) after percutaneous vertebral augmentation may be an issue that cannot be ignored. Nevertheless, the risk factors for NVCF are still uncertain. This research aimed to study the risk factors for NVCF after percutaneous vertebral augmentation. MATERIAL AND METHODS All patients who underwent percutaneous vertebral augmentation for OVCF from January 2019 to December 2020 were enrolled in the study. These patients were divided into NVCF and control groups according to whether they had NVCF. The covariates including sex, age, BMI, diabetes, hypertension, smoking, alcohol, fracture level, surgical method, cement leakage, cement volume, preoperative anterior vertebral height ratio, and Hounsfield unit (HU) value were reviewed. Univariate and multivariate analyses were performed to identify risk factors. RESULTS A total of 279 patients were included in this study, of which 47 had NVCF after percutaneous vertebral augmentation. Univariate analysis demonstrated that there were significant differences in age (OR=1.040, 95% CI=1.003-1.078, P=0.033), BMI (OR=0.844, 95% CI=0.758-0.939, P=0.002) and HU value (OR=0.945, 95% CI=0.929-0.962, P<0.001) between the 2 groups. Multivariate regression analysis revealed that HU value (OR=0.942, 95% CI=0.924-0.960, P<0.001) were independent risk factor for NVCF after percutaneous vertebral augmentation. CONCLUSIONS Hounsfield unit value was an independent risk factor for new vertebral compression fracture after percutaneous vertebral augmentation, whereas age and BMI were not.
经皮椎体强化术是骨质疏松性椎体压缩骨折（OVCF）的主流治疗方法。经皮椎体强化术后新发椎体压缩骨折（NVCF）可能是一个不容忽视的问题。然而，NVCF 的危险因素仍不确定。本研究旨在探讨经皮椎体强化术后 NVCF 的危险因素。
本研究纳入了 2019 年 1 月至 2020 年 12 月期间因 OVCF 接受经皮椎体强化术的所有患者。根据是否发生 NVCF，这些患者被分为 NVCF 组和对照组。回顾了性别、年龄、BMI、糖尿病、高血压、吸烟、饮酒、骨折节段、手术方法、水泥渗漏、水泥量、术前前柱高度比和 Hounsfield 单位（HU）值等混杂因素。进行单因素和多因素分析以确定危险因素。
本研究共纳入 279 例患者，其中 47 例患者经皮椎体强化术后发生 NVCF。单因素分析表明，年龄（OR=1.040，95%CI=1.003-1.078，P=0.033）、BMI（OR=0.844，95%CI=0.758-0.939，P=0.002）和 HU 值（OR=0.945，95%CI=0.929-0.962，P<0.001）在两组间存在显著差异。多因素回归分析显示，HU 值（OR=0.942，95%CI=0.924-0.960，P<0.001）是经皮椎体强化术后发生 NVCF 的独立危险因素。
HU 值是经皮椎体强化术后发生 NVCF 的独立危险因素，而年龄和 BMI 不是。
