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[男性和女性的甲状腺疾病——现状与新的研究需求]

[Diseases of the thyroid gland in men and women-Status quo and new research needs].

作者信息

Lampropoulou E, Brandenburg T, Führer D

机构信息

Klinik für Endokrinologie, Diabetologie und Stoffwechsel, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen, Deutschland.

Endokrines Tumorzentrum mit ENETS Center of Excellence, Westdeutsches Tumorzentrum (WTZ) Essen, Essen, Deutschland.

出版信息

Inn Med (Heidelb). 2023 Aug;64(8):758-765. doi: 10.1007/s00108-023-01553-7. Epub 2023 Jul 18.

DOI:10.1007/s00108-023-01553-7
PMID:37462691
Abstract

"Diseases of the thyroid gland occur more frequently in women": this statement has been used in textbooks for decades; however, is this equally true for all thyroid gland diseases and can conclusions be derived from this for a different disease relevance and prognosis in men and women? Is possibly even a sex-specific treatment needed? These questions are taken up and subsequently the epidemiological data and studies that have investigated the influence of gender on the course of thyroid gland diseases are taken into consideration. It is shown that the data situation is much more restricted than is to be expected for frequent diseases in the general population.

摘要

“甲状腺疾病在女性中更为常见”:这一说法已在教科书中沿用数十年;然而,对于所有甲状腺疾病而言,情况是否都是如此?能否据此得出男女在不同疾病相关性和预后方面的结论?甚至是否可能需要针对性别进行治疗?本文将探讨这些问题,随后会考虑流行病学数据以及研究性别对甲状腺疾病病程影响的各项研究。结果表明,与普通人群中常见疾病的预期情况相比,相关数据极为有限。

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本文引用的文献

1
The Impact of Age- and Sex-Specific Reference Ranges for Serum Thyrotropin and Free Thyroxine on the Diagnosis of Subclinical Thyroid Dysfunction: A Multicenter Study from Japan.年龄和性别特异性血清促甲状腺激素和游离甲状腺素参考范围对亚临床甲状腺功能障碍诊断的影响:来自日本的一项多中心研究。
Thyroid. 2023 Apr;33(4):428-439. doi: 10.1089/thy.2022.0567. Epub 2023 Mar 22.
2
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Gesundheitswesen. 2023 Mar;85(3):175-180. doi: 10.1055/a-1806-0707. Epub 2022 Oct 4.
3
Diagnosis of thyroid nodules.
甲状腺结节的诊断。
Lancet Diabetes Endocrinol. 2022 Jul;10(7):533-539. doi: 10.1016/S2213-8587(22)00101-2.
4
The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020.全球甲状腺癌的流行病学概况:2020 年发病率和死亡率的 GLOBOCAN 估计。
Lancet Diabetes Endocrinol. 2022 Apr;10(4):264-272. doi: 10.1016/S2213-8587(22)00035-3. Epub 2022 Mar 7.
5
Cancer statistics, 2022.癌症统计数据,2022 年。
CA Cancer J Clin. 2022 Jan;72(1):7-33. doi: 10.3322/caac.21708. Epub 2022 Jan 12.
6
Sex Differences in Differentiated Thyroid Cancer.分化型甲状腺癌中的性别差异
Thyroid. 2022 Mar;32(3):224-235. doi: 10.1089/thy.2021.0361.
7
TSH concentrations in parents and their offspring: a cross-sectional family-based analysis.父母及其子女的 TSH 浓度:一项基于家庭的横断面分析。
Eur J Endocrinol. 2021 Nov 26;185(6):855-862. doi: 10.1530/EJE-21-0652.
8
Does Age or Sex Relate to Severity or Treatment Prognosis in Graves' Disease?年龄或性别与格雷夫斯病的严重程度或治疗预后有关吗?
Thyroid. 2021 Sep;31(9):1409-1415. doi: 10.1089/thy.2020.0881. Epub 2021 May 26.
9
2021 European Thyroid Association Guideline on Thyroid Disorders prior to and during Assisted Reproduction.2021年欧洲甲状腺协会关于辅助生殖之前及期间甲状腺疾病的指南。
Eur Thyroid J. 2021 Feb;9(6):281-295. doi: 10.1159/000512790. Epub 2021 Jan 21.
10
Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses.年龄和性别影响甲状腺激素在具有器官特异性反应的靶组织中的作用。
Exp Clin Endocrinol Diabetes. 2020 Jun;128(6-07):469-472. doi: 10.1055/a-1083-6272. Epub 2020 Jan 13.