Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Vakilabad Blvd, Pardis University Campus, Mashhad, 91886 17871, Iran.
Neurochem Res. 2023 Nov;48(11):3270-3282. doi: 10.1007/s11064-023-03986-w. Epub 2023 Jul 18.
Neurological disorders are the leading cause of disability and the world's second leading cause of death. Despite the availability of significant knowledge to reduce the burden of some neurological disorders, various studies are exploring more effective treatment options. While the human body can repair and regenerate damaged tissue through stem cell recruitment, nerve regeneration in case of injury is minimal due to the restriction on the location of nerve stem cells. Recently, different types of stem cells extracted from various tissues have been used in combination with natural stimuli to treat neurologic disorders in neuronal tissue engineering. Flavonoids are polyphenolic compounds that can induce the differentiation of stem cells into neurons and stimulate stem cell proliferation, migration, and survival. They can also increase the secretion of nutritional factors from stem cells. In addition to the effects that flavonoids can have on stem cells, they can also have beneficial therapeutic effects on the nervous system alone. Therefore, the simultaneous use of these compounds and stem cells can multiply the therapeutic effect. In this review, we first introduce flavonoid compounds and provide background information on stem cells. We then compile available reports on the effects of flavonoids on stem cells for the treatment of neurological disorders.
神经紊乱是造成残疾的首要原因，也是全球的第二大致死原因。尽管已有大量知识可用于减轻一些神经紊乱的负担，但各种研究仍在探索更有效的治疗选择。虽然人体可以通过干细胞募集来修复和再生受损组织，但由于神经干细胞位置受限，损伤后神经再生的程度非常有限。最近，已从各种组织中提取出不同类型的干细胞，并与天然刺激物联合用于神经元组织工程中治疗神经紊乱。类黄酮是一种多酚化合物，可诱导干细胞向神经元分化，并刺激干细胞增殖、迁移和存活。类黄酮还可以增加干细胞分泌营养因子。除了类黄酮对干细胞的作用外，类黄酮本身对神经系统也有有益的治疗作用。因此，同时使用这些化合物和干细胞可以使治疗效果加倍。在本综述中，我们首先介绍类黄酮化合物，并提供有关干细胞的背景信息。然后，我们汇编了关于类黄酮对干细胞治疗神经紊乱影响的现有报告。
