Holzer-Petsche U, Rinner I, Lembeck F
J Neural Transm. 1986;66(2):85-92. doi: 10.1007/BF01260904.
Choline acetyltransferase (CAT) activity was measured in various regions of rat spinal cord. In the ventral cord, enzyme activity was 2 to 3 times higher than in dorsal cord. In dorsal spinal cord, there was a gradient in enzyme activity, increasing CAT activity being observed in more caudal segments. In autonomic regions intermediate levels were measured. Bilateral transection of the sciatic nerve reduced CAT activity in the ventral horn of lumbar spinal cord, whereas CAT activity in the dorsal horn remained unchanged. Capsaicin pretreatment had no effect on CAT activity in any spinal cord region. Although a similar distribution of cholinergic neurones and primary afferent endings in rat dorsal spinal cord was described, no conclusive statement as to a possible functional interaction can be given.
在大鼠脊髓的不同区域测量了胆碱乙酰转移酶（CAT）的活性。在脊髓腹侧，酶活性比背侧高2至3倍。在脊髓背侧，酶活性存在梯度变化，在更靠尾端的节段中观察到CAT活性增加。在自主神经区域测量到的是中间水平。坐骨神经双侧横断降低了腰脊髓腹角的CAT活性，而背角的CAT活性保持不变。辣椒素预处理对任何脊髓区域的CAT活性均无影响。尽管已经描述了大鼠脊髓背侧胆碱能神经元和初级传入末梢的类似分布，但关于可能的功能相互作用无法给出确凿的结论。
