Scattolin Thomas, Tonon Giovanni, Botter Eleonora, Guillet Sebastien G, Tzouras Nikolaos V, Nolan Steven P
Dipartimento di Scienze Chimiche, Università degli studi di Padova, via Marzolo 1, 35131, Padova, Italy.
Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca' Foscari Campus Scientifico, Via Torino 155, 30174, Venezia-Mestre, Italy.
Chemistry. 2023 Oct 18;29(58):e202301961. doi: 10.1002/chem.202301961. Epub 2023 Sep 7.
The prominent role of gold-N-heterocyclic carbene (NHC) complexes in numerous research areas such as homogeneous (photo)catalysis, medicinal chemistry and materials science has prompted organometallic chemists to design gold-based synthons that permit access to target complexes through simple synthetic steps under mild conditions. In this review, the main gold-NHC synthons employed in organometallic synthesis are discussed. Mechanistic aspects involved in their synthesis and reactivity as well as applications of gold-NHC synthons as efficient pre-catalysts, antitumor agents and/or photo-emissive materials are presented.
金 - N - 杂环卡宾（NHC）配合物在众多研究领域，如均相（光）催化、药物化学和材料科学中发挥着重要作用，这促使有机金属化学家设计基于金的合成子，以便在温和条件下通过简单的合成步骤获得目标配合物。在这篇综述中，讨论了有机金属合成中使用的主要金 - NHC合成子。介绍了其合成和反应性所涉及的机理方面，以及金 - NHC合成子作为高效预催化剂、抗肿瘤剂和/或光发射材料的应用。
