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用于心电图描绘和室性早搏检测的二阶过零采样模数转换器

Second-Order Level-Crossing Sampling Analog to Digital Converter for Electrocardiogram Delineation and Premature Ventricular Contraction Detection.

作者信息

Tang Xiaochen, Renteria-Pinon Mario, Tang Wei

出版信息

IEEE Trans Biomed Circuits Syst. 2023 Dec;17(6):1342-1354. doi: 10.1109/TBCAS.2023.3296529. Epub 2024 Jan 10.

Abstract

This article presents an electrocardiogram (ECG) delineation and arrhythmia heartbeat detection system using a novel second-order level-crossing sampling analog to digital converter (ADC) for real-time data compression and feature extraction. The proposed system consists of the front-end integrated circuit of the data converter, the delineation algorithm, and the arrhythmia detection algorithm. Compared with conventional level-sampling ADCs, the proposed circuit updates tracking thresholds using linear extrapolation, which forms a second-order level-crossing sampling ADC that has sloped sampling levels. The computing is done digitally and is implemented by modifying the digital control logic of a conventional Successive-approximation-register (SAR) ADC. The system separates the sampling and quantization processes and only selects the turning points in the input waveform for quantization. The output of the proposed data converter consists of both the digital value of the selected sampling points and the timestamp between the selected sampling points. The main advantages are data savings for the data converter and the following digital signal processing or communication circuits, which are ideal for low-power sensors. The test chip was fabricated using a 180 nm CMOS process. When sensing sparse signals such as ECG signals the proposed ADC achieves a compression factor of 8.33. The delineation algorithm uses a triangle filter method to locate the fiducial points and measures the intervals, slopes, and morphology of the QRS complex and the P/T waves. Those extracted features are then used in the arrhythmia heartbeat detection algorithm to identify Premature Ventricular Contraction (PVC). The overall performance of the system is evaluated using the MIT-BIH database and the QT database, which is also compared with the recently reported systems. The accuracy, sensitivity, specificity, PPV, and F1 score are 97.3%, 89.6%, 97.8%, 73.3%, and 0.81 for detecting PVC.

摘要

本文介绍了一种心电图(ECG)描绘和心律失常心跳检测系统,该系统使用一种新型的二阶过零采样模数转换器(ADC)进行实时数据压缩和特征提取。所提出的系统由数据转换器的前端集成电路、描绘算法和心律失常检测算法组成。与传统的电平采样ADC相比,所提出的电路使用线性外推法更新跟踪阈值,形成了具有倾斜采样电平的二阶过零采样ADC。计算通过数字方式完成,并通过修改传统逐次逼近寄存器(SAR)ADC的数字控制逻辑来实现。该系统将采样和量化过程分开,只选择输入波形中的转折点进行量化。所提出的数据转换器的输出包括所选采样点的数字值以及所选采样点之间的时间戳。主要优点是为数据转换器以及后续的数字信号处理或通信电路节省了数据,这对于低功耗传感器来说是理想的。测试芯片采用180 nm CMOS工艺制造。当感测诸如ECG信号之类的稀疏信号时,所提出的ADC实现了8.33的压缩因子。描绘算法使用三角滤波器方法来定位基准点,并测量QRS波群以及P/T波的间期、斜率和形态。然后将这些提取的特征用于心律失常心跳检测算法中,以识别室性早搏(PVC)。使用麻省理工学院 - 贝斯以色列女执事医疗中心(MIT - BIH)数据库和QT数据库对系统的整体性能进行评估,并与最近报道的系统进行比较。对于检测PVC,准确率、灵敏度、特异性、阳性预测值和F1分数分别为97.3%、89.6%、97.8%、73.3%和0.81。

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