纤维肌痛综合征患者 5-羟色胺转运体基因（5-HTT VNTR 和 5-HTTLPR）多态性的相关性评估。

ASSESSMENT OF THE ASSOCIATION OF SEROTONIN TRANSPORTER GENE (5-HTTVNTR & 5-HTTLPR) POLYMORPHISM IN PATIENTS WITH FIBROMYALGIA SYNDROME.

机构信息

ERA UNIVERSITY, LUCKNOW, INDIA.

UNIVERSITY OF KUFA, NAJAF, IRAQ.

出版信息

Wiad Lek. 2023;76(6):1378-1384. doi: 10.36740/WLek202306108.

DOI:10.36740/WLek202306108

PMID:37463371

Abstract

OBJECTIVE

The aim: To study the clinical and the genetic association of 5-HTTVNTR and the 5-HTTLPR polymorphisms in women with FMS.

PATIENTS AND METHODS

Materials and methods: 105 FMS patients and 105 controls were enrolled in the study. Polymerase chain method was used to analyse the 5-HTTLPR & 5-HTTVNTR gene polymorphism. The psychopathology status of the 105 FMS patients and 105 healthy controls was assessed using the Beck Depression Inventory (BDI) and the Symptom Checklist-90-Revised (SCL-90-R) questionnaires.

RESULTS

Results: In FMS patients and controls, the 10/10, 10/12, and 12/12 genotypes of the 5-HTTVNTR polymorphism were found in 3.8% and 2.9%, 20% and 15.2%, and 76.28% and 81.90%, respectively. Additionally, the L/L, S/L, and S/S genotypes of the 5-HTTLPR polymorphism were found in 4.8% and 2.9%, 36.2% and 40%, 59% and 57.1%, in FMS patients and healthy controls, respectively. There were no significant differences in the frequency of genotypes between FMS patients and controls. There were no significant differences in the BDI and the SCL-90-R scores according to the serotonin transporter genotypes.

CONCLUSION

Conclusions: We found no significant difference between 5-HTT gene polymorphism (5-HTTVNTR and 5-HTTLPR) and the psychiatric test results (P>0.05) in FMS patients. Hence, we conclude that serotonin gene polymorphism (5-HTTLPR & 5-HTTVNTR) is not associated with FMS in north Indian women. Our results suggests that the serotonin transporter polymorphism does not seem to be a susceptibility factor for FMS.

摘要

目的

研究 5-HTTVNTR 和 5-HTTLPR 多态性与纤维肌痛综合征（FMS）女性患者的临床和遗传相关性。

患者与方法

105 例 FMS 患者和 105 例对照者纳入本研究。采用聚合酶链法分析 5-HTTLPR 和 5-HTTVNTR 基因多态性。采用贝克抑郁量表（BDI）和症状自评量表-90 修订版（SCL-90-R）评估 105 例 FMS 患者和 105 例健康对照者的精神病理学状态。

结果

在 FMS 患者和对照组中，5-HTTVNTR 多态性的 10/10、10/12 和 12/12 基因型分别为 3.8%和 2.9%、20%和 15.2%、76.28%和 81.90%。此外，5-HTTLPR 多态性的 L/L、S/L 和 S/S 基因型在 FMS 患者和健康对照组中分别为 4.8%和 2.9%、36.2%和 40%、59%和 57.1%。FMS 患者和对照组之间的基因型频率无显著差异。根据 5-羟色胺转运体基因型，BDI 和 SCL-90-R 评分无显著差异。

结论

我们发现 FMS 患者 5-羟色胺基因多态性（5-HTTVNTR 和 5-HTTLPR）与精神测试结果之间无显著差异（P＞0.05）。因此，我们得出结论，5-羟色胺基因多态性（5-HTTLPR 和 5-HTTVNTR）与印度北部女性的 FMS 无关。我们的结果表明，5-羟色胺转运体多态性似乎不是 FMS 的易感因素。