Parvez Sidrah, Dzupina Andrej, Fatima Ghizal, Fedacko Jan, Magomedova Aminat, Mehdi Abbas A
Department of Biotechnology, Era University, Era's Lucknow Medical College and Hospital, Lucknow, IND.
Department of Cardiology and Angiology, National Institute of Cardiovascular Diseases, Bratislava, SVK.
Cureus. 2024 Dec 6;16(12):e75210. doi: 10.7759/cureus.75210. eCollection 2024 Dec.
Purpose Fibromyalgia syndrome (FMS) presents a chronic pain condition affecting muscles and joints. Investigating circadian rhythms' disruption, integral to physiological responses, this study delves into the potential impact of gene polymorphism (rs57875989) on FMS pathogenesis. Methods In this study, we investigated gene polymorphism in 100 FMS patients and an equal number of control individuals. The genotyping of the gene polymorphism was conducted using polymerase chain reaction (PCR) methodology. Subsequently, we evaluated the association between gene polymorphism and FMS susceptibility using odds ratios (ORs) and 95% confidence intervals (CIs) by comparing the genotype and allele frequencies of the gene polymorphism between FMS patients and controls. Results The gene revealed three genotypes: 4/4, 4/5, and 5/5, with allele frequencies showing significant associations between FMS patients and controls (p<0.05). Notably, gene polymorphism was linked to FMS development, particularly the 4/4 genotype versus the combined 4/5 and 5/5 genotypes (OR=2.85; 95% CI, 1.35-6.0; p=0.008). These findings suggest a potential role of gene variation as a genetic risk factor for FMS. Conclusion These findings reported a potential association between gene polymorphism and FMS, illuminating novel pathways for comprehending and addressing this complex condition. This study holds promise for advancing our understanding of FMS etiology and may inform the development of innovative management strategies tailored to individual genetic profiles, potentially leading to more effective treatments and improved outcomes for patients grappling with FMS.
目的 纤维肌痛综合征（FMS）是一种影响肌肉和关节的慢性疼痛病症。昼夜节律紊乱是生理反应的重要组成部分，本研究深入探讨基因多态性（rs57875989）对FMS发病机制的潜在影响。方法 在本研究中，我们调查了100例FMS患者和同等数量对照个体的基因多态性。使用聚合酶链反应（PCR）方法对基因多态性进行基因分型。随后，通过比较FMS患者和对照之间基因多态性的基因型和等位基因频率，使用优势比（OR）和95%置信区间（CI）评估基因多态性与FMS易感性之间的关联。结果 该基因显示出三种基因型：4/4、4/5和5/5，等位基因频率在FMS患者和对照之间显示出显著关联（p<0.05）。值得注意的是，基因多态性与FMS的发生有关，特别是4/4基因型与4/5和5/5基因型组合相比（OR=2.85；95%CI，1.35-6.0；p=0.008）。这些发现表明基因变异作为FMS遗传风险因素的潜在作用。结论 这些发现报告了基因多态性与FMS之间的潜在关联，为理解和解决这一复杂病症开辟了新途径。本研究有望增进我们对FMS病因的理解，并可能为根据个体基因谱制定创新管理策略提供信息，有可能为患有FMS的患者带来更有效的治疗和更好的结果。
