抑郁与肌肉减少症：一项孟德尔随机化分析。

Depression and sarcopenia: a Mendelian randomization analysis.

机构信息

Department of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University.

Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.

出版信息

Psychiatr Genet. 2023 Aug 1;33(4):145-151. doi: 10.1097/YPG.0000000000000346. Epub 2023 Jun 12.

DOI:10.1097/YPG.0000000000000346

PMID:37463392

Abstract

BACKGROUND

The association between depression and sarcopenia has been reported in observational studies but the causality of depression on sarcopenia remained unknown. We aimed to assess the causal effect between major depressive disorder (MDD) and sarcopenia using the two-sample Mendelian randomization (MR) method.

METHODS

A set of genetics instruments were used for analysis, derived from publicly available genetic summary data. Clinically, appendicular lean mass (ALM) and low hand grip strength (LHGS) have been widely used for the diagnosis of sarcopenia. Inverse-variance weighted method, weighted median method, MR-Egger, MR Pleiotropy RESidual Sum and Outlier test were used for the bidirectional MR analyses.

RESULTS

No evidence for an effect of MDD on sarcopenia risk was found. MDD was not associated with ALM [effect = -0.17 (-0.60 to 0.27), P = 0.449] and LHGS [effect = 0.24 (-0.46 to 0.93), P = 0.506]. Sarcopenia was not associated with MDD [ALM: odds ratio (OR) = 0.999 (0.996-1.001), P = 0.374; LHGS: OR = 0.999 (0.996-1.002), P = 0.556].

CONCLUSION

MDD and Sarcopenia might mutually have no causal effect on each other.

摘要

背景

观察性研究已经报道了抑郁与肌肉减少症之间的关联，但抑郁对肌肉减少症的因果关系尚不清楚。我们旨在使用两样本 Mendelian 随机化 (MR) 方法评估重度抑郁症 (MDD) 和肌肉减少症之间的因果关系。

方法

使用一组遗传工具进行分析，这些工具源自公开可用的遗传汇总数据。临床上，四肢瘦组织（ALM）和低手握力（LHGS）已广泛用于肌肉减少症的诊断。使用逆方差加权法、加权中位数法、MR-Egger、MR 偏倚 RESidual Sum 和异常值检验进行双向 MR 分析。

结果

没有证据表明 MDD 会增加肌肉减少症的风险。MDD 与 ALM 无关[效应值=-0.17（-0.60 至 0.27），P=0.449]和 LHGS[效应值=0.24（-0.46 至 0.93），P=0.506]。肌肉减少症与 MDD 无关[ALM：比值比（OR）=0.999（0.996-1.001），P=0.374；LHGS：OR=0.999（0.996-1.002），P=0.556]。