• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Reclaiming the Balance: Blocking Glutamine Uptake to Restrain Pulmonary Fibrosis.

作者信息

Liu Gang, Summer Ross

机构信息

School of Life Sciences University of Technology Sydney Ultimo, New South Wales, Australia.

Centre for Inflammation Centenary Institute and University of Technology Sydney Camperdown, New South Wales, Australia.

出版信息

Am J Respir Cell Mol Biol. 2023 Oct;69(4):378-379. doi: 10.1165/rcmb.2023-0189ED.

DOI:10.1165/rcmb.2023-0189ED
PMID:37463521
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10557921/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ce/10557921/ac989d54c9d0/rcmb.2023-0189EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ce/10557921/ac989d54c9d0/rcmb.2023-0189EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92ce/10557921/ac989d54c9d0/rcmb.2023-0189EDf1.jpg

相似文献

1
Reclaiming the Balance: Blocking Glutamine Uptake to Restrain Pulmonary Fibrosis.恢复平衡：阻断谷氨酰胺摄取以抑制肺纤维化
Am J Respir Cell Mol Biol. 2023 Oct;69(4):378-379. doi: 10.1165/rcmb.2023-0189ED.
2
The glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: transport mechanism, regulation by ATP and characterization of the glutamine/glutamate antiport.脂质体中重组的谷氨酰胺/氨基酸转运体（ASCT2）：转运机制、ATP调节及谷氨酰胺/谷氨酸反向转运的特性
Biochim Biophys Acta. 2007 Feb;1768(2):291-8. doi: 10.1016/j.bbamem.2006.09.002. Epub 2006 Sep 16.
3
Characterization of L-glutamine transport by a human neuroblastoma cell line.人神经母细胞瘤细胞系对L-谷氨酰胺转运的特性研究
Am J Physiol Cell Physiol. 2002 Jun;282(6):C1246-53. doi: 10.1152/ajpcell.00324.2001.
4
Impairment of Myocardial Glutamine Homeostasis Induced By Suppression of the Amino Acid Carrier SLC1A5 in Failing Myocardium.衰竭心肌中氨基酸载体SLC1A5的抑制导致心肌谷氨酰胺稳态受损。
Circ Heart Fail. 2019 Dec;12(12):e006336. doi: 10.1161/CIRCHEARTFAILURE.119.006336. Epub 2019 Dec 12.
5
Targeting glutamine transport to suppress melanoma cell growth.靶向谷氨酰胺转运以抑制黑素瘤细胞生长。
Int J Cancer. 2014 Sep 1;135(5):1060-71. doi: 10.1002/ijc.28749. Epub 2014 Feb 17.
6
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.氨基酸转运体ASCT2（SLC1A5）的缺失揭示了转运体SNAT1（SLC38A1）和SNAT2（SLC38A2）在维持癌细胞谷氨酰胺分解代谢中的重要作用。
J Biol Chem. 2016 Jun 17;291(25):13194-205. doi: 10.1074/jbc.M115.700534. Epub 2016 Apr 26.
7
In Vitro Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine-Serine-Cysteine Transporter 2.体外研究视网膜周细胞中 L-谷氨酸和 L-谷氨酰胺的转运：兴奋性氨基酸转运体 1 和丙氨酸-丝氨酸-半胱氨酸转运体 2 的参与。
Biol Pharm Bull. 2015;38(6):901-8. doi: 10.1248/bpb.b15-00133.
8
TEAD1 (TEA Domain Transcription Factor 1) Promotes Smooth Muscle Cell Proliferation Through Upregulating SLC1A5 (Solute Carrier Family 1 Member 5)-Mediated Glutamine Uptake.TEAD1（TEA 结构域转录因子 1）通过上调 SLC1A5（溶质载体家族 1 成员 5）介导的谷氨酰胺摄取促进平滑肌细胞增殖。
Circ Res. 2019 Apr 26;124(9):1309-1322. doi: 10.1161/CIRCRESAHA.118.314187.
9
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation.炎症 T 细胞反应依赖于氨基酸转运蛋白 ASCT2 促进谷氨酰胺摄取和 mTORC1 激酶激活。
Immunity. 2014 May 15;40(5):692-705. doi: 10.1016/j.immuni.2014.04.007. Epub 2014 May 1.
10
Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons.谷氨酰胺在小鼠小脑和大脑皮质星形胶质细胞及神经元中的摄取以及谷氨酰胺转运蛋白mRNA的表达。
Neurochem Int. 2004 Jan;44(2):75-81. doi: 10.1016/s0197-0186(03)00123-2.

引用本文的文献

1
Causal relationship between circulating glutamine levels and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study.循环谷氨酰胺水平与特发性肺纤维化之间的因果关系：两样本孟德尔随机化研究。
BMC Pulm Med. 2024 Sep 13;24(1):451. doi: 10.1186/s12890-024-03275-4.

本文引用的文献

1
Targeting Pulmonary Fibrosis by SLC1A5-Dependent Glutamine Transport Blockade.靶向 SLC1A5 依赖的谷氨酰胺转运抑制治疗肺纤维化
Am J Respir Cell Mol Biol. 2023 Oct;69(4):441-455. doi: 10.1165/rcmb.2022-0339OC.
2
Glutamine Metabolism Is Required for Alveolar Regeneration during Lung Injury.谷氨酰胺代谢是肺损伤时肺泡再生所必需的。
Biomolecules. 2022 May 22;12(5):728. doi: 10.3390/biom12050728.
3
Glutamine restores mitochondrial respiration in bleomycin-injured epithelial cells.谷氨酰胺可恢复博莱霉素损伤的上皮细胞中的线粒体呼吸。
Free Radic Biol Med. 2021 Nov 20;176:335-344. doi: 10.1016/j.freeradbiomed.2021.10.006. Epub 2021 Oct 8.
4
Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy.增强谷氨酰胺代谢抑制剂在癌症治疗中的疗效。
Trends Cancer. 2021 Aug;7(8):790-804. doi: 10.1016/j.trecan.2021.04.003. Epub 2021 May 18.
5
Therapeutic targets in lung tissue remodelling and fibrosis.肺组织重塑和纤维化的治疗靶点。
Pharmacol Ther. 2021 Sep;225:107839. doi: 10.1016/j.pharmthera.2021.107839. Epub 2021 Mar 25.
6
Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.纤维结合蛋白-1c 调节肺组织纤维化中转化生长因子-β的激活。
JCI Insight. 2019 Jul 25;5(16):124529. doi: 10.1172/jci.insight.124529.
7
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.谷氨酰胺代谢是肺成纤维细胞胶原蛋白合成所必需的。
Am J Respir Cell Mol Biol. 2019 Nov;61(5):597-606. doi: 10.1165/rcmb.2019-0008OC.
8
Inhibition of Glutaminase 1 Attenuates Experimental Pulmonary Fibrosis.抑制谷氨酰胺酶 1 可减轻实验性肺纤维化。
Am J Respir Cell Mol Biol. 2019 Oct;61(4):492-500. doi: 10.1165/rcmb.2019-0051OC.
9
Idiopathic Pulmonary Fibrosis.特发性肺纤维化
N Engl J Med. 2018 Aug 23;379(8):797-798. doi: 10.1056/NEJMc1807508.
10
Lung Fibroblasts, Aging, and Idiopathic Pulmonary Fibrosis.肺成纤维细胞、衰老与特发性肺纤维化
Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S417-S421. doi: 10.1513/AnnalsATS.201605-341AW.