免疫治疗引起的单纯皮肤类肉瘤样反应。
Immunotherapy-induced exclusively cutaneous sarcoid-like reaction.
机构信息
Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
出版信息
BMJ Case Rep. 2023 Jul 18;16(7):e252766. doi: 10.1136/bcr-2022-252766.
Sarcoid-like reactions (SLRs) are rare, granulomatous inflammatory reactions to immune checkpoint inhibitors (ICIs) that can involve any organ but frequently affect the lungs, mediastinal lymph nodes and skin. We present a rare case of an exclusively cutaneous SLR due to pembrolizumab that clinically resembled dermatomyositis. A literature review yielded only 12 previously reported cases of ICI-induced cutaneous SLR without any systemic involvement. Our case highlights the diversity of presentations of cutaneous SLR and emphasises the importance of histological evaluation of new cutaneous eruptions.
肉瘤样反应（SLR）是一种罕见的免疫检查点抑制剂（ICI）引起的肉芽肿性炎症反应，可累及任何器官，但常累及肺部、纵隔淋巴结和皮肤。我们报告了一例由 pembrolizumab 引起的罕见的仅累及皮肤的 SLR，其临床表现类似于皮肌炎。文献复习仅发现 12 例先前报道的 ICI 诱导的无任何系统受累的皮肤 SLR 病例。我们的病例突出了皮肤 SLR 表现的多样性，并强调了对新出现的皮肤疹进行组织学评估的重要性。
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