Çukurova University Faculty of Medicine Department of Medical Oncology, Adana, Turkey.
Med Oncol. 2021 Feb 18;38(3):29. doi: 10.1007/s12032-021-01477-y.
Sarcoidosis is a multisystem granulomatous disorder characterized by helper T cell inflammation. Sarcoid-like reaction (SLR) is a well-defined entity and may be related with several malignant disorders and/or their therapies. SLR has been reported more than 20 years ago and in recent years in cases treated by checkpoint inhibitors (CPIs). Better outcome has been reported in cases developing granulomatous reaction and/or SLRs during CPI treatments. However, these lesions clinically may be thought as disease progression and may cause to stop treatment or alterations. These therapeutic manipulations may be harmful for the patients. Clinicians should be aware of SLRs in cases treated by CPIs and tissues must be sampled and reviewed by an experienced pathologist to avoid misdiagnosis and also unnecessary CPI treatment cessations.Significance StatementClinicians should be aware of sarcoid-like reactions in cases treated by checkpoint inhibitors and tissues must be sampled and reviewed by an experienced pathologist to avoid misdiagnosis and CPI treatment stops.
结节病是一种多系统肉芽肿性疾病，其特征是辅助性 T 细胞炎症。类肉瘤样反应（SLR）是一种明确的实体，可能与多种恶性疾病及其治疗方法有关。SLR 早在 20 多年前就有报道，近年来在接受检查点抑制剂（CPIs）治疗的病例中也有报道。在 CPI 治疗过程中出现肉芽肿性反应和/或 SLR 的病例报告的结果更好。然而，这些病变在临床上可能被认为是疾病进展，并可能导致停止治疗或改变治疗方案。这些治疗干预可能对患者有害。临床医生应该意识到接受 CPIs 治疗的病例中存在 SLR，必须由有经验的病理学家对组织进行取样和检查，以避免误诊和不必要的 CPI 治疗停止。
接受检查点抑制剂治疗的病例中可能存在类肉瘤样反应，临床医生应该意识到这一点，必须由有经验的病理学家对组织进行取样和检查，以避免误诊和 CPI 治疗停止。
