Division of Field Studies and Engineering, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA.
Department of Epidemiology and Environmental Health, College of Public Health, University of Kentucky, Lexington, Kentucky, USA.
Am J Ind Med. 2023 Oct;66(10):842-853. doi: 10.1002/ajim.23516. Epub 2023 Jul 18.
Potential reproductive effects of organic solvent exposure during pregnancy remain unclear. We investigated the association between maternal occupational exposure during pregnancy to six chlorinated solvents, three aromatic solvents, and Stoddard solvent, and delivery of preterm infants or those born small-for-gestational age (SGA).
In this case-control study of SGA and preterm birth (PTB) nested within the National Birth Defects Prevention Study (NBDPS) from 1997 to 2011, we analyzed data from 7504 singleton live births without major birth defects and their mothers. Self-reported information on jobs held in the periconceptional period was assessed for solvent exposure. Unconditional logistic regression was used to estimate the association between maternal occupational exposure (any, none) during early pregnancy to organic solvents and PTB and SGA. Linear regression was used to examine changes in mean birthweight potentially associated with maternal occupational solvent exposure.
Maternal occupational exposure to any organic solvents overall was not associated with an increased odds of PTB (adjusted odds ratio [aOR] = 0.94; 95% confidence interval [CI] 0.67-1.33) or SGA (aOR = 0.93; 95% CI 0.65-1.34). Point estimates increased modestly for higher estimated exposure versus lower, but confidence intervals were wide and not statistically significant. Maternal exposure to solvents was not associated with a statistically significant change in term birthweight among infants.
Occupational exposure to organic solvents at the frequency and intensity levels found in a population-based sample of pregnant workers was not associated with PTB or SGA; however, we cannot rule out any effects among pregnant workers with uncommonly high exposure to organic solvents.
孕期接触有机溶剂潜在的生殖影响仍不清楚。我们调查了孕妇在怀孕期间职业性接触六种氯化溶剂、三种芳香族溶剂和斯多达溶剂与早产儿或小于胎龄儿(SGA)分娩的关系。
在这项 1997 年至 2011 年期间嵌套于国家出生缺陷预防研究(NBDPS)中的 SGA 和早产(PTB)病例对照研究中,我们分析了 7504 名无重大出生缺陷的单胎活产儿及其母亲的数据。评估了妊娠早期母亲职业暴露于溶剂的情况,采用非条件逻辑回归估计母亲妊娠早期职业暴露(有或无)于有机溶剂与 PTB 和 SGA 的关系。线性回归用于检查可能与母亲职业溶剂暴露相关的平均出生体重变化。
总体而言,母亲职业性接触有机溶剂与 PTB(校正比值比[aOR] = 0.94;95%置信区间[CI] 0.67-1.33)或 SGA(aOR = 0.93;95%CI 0.65-1.34)的风险增加无关。与低估计暴露相比,较高估计暴露的点估计值略有增加,但置信区间较宽且无统计学意义。溶剂暴露与足月婴儿的出生体重无统计学显著变化相关。
在孕妇人群中,以基于人群的样本中发现的频率和强度接触有机溶剂量,职业接触有机溶剂与 PTB 或 SGA 无关;然而,我们不能排除职业性接触有机溶剂水平异常高的孕妇中存在任何影响。