Ofek I, Whitaker J N, Campbell G L, Beachey E H
J Infect Dis. 1979 Jan;139(1):93-6. doi: 10.1093/infdis/139.1.93.
Group A streptococcal lipoteichoic acid (LTA), a polyglycerol phosphate ester linked with fatty acids, formed precipitin lines in agar gels with the positively charged myelin basic protein (MBP) isolated from bovine brain. The LTA-MBP complexes were formed with deacylated teichoic acid and were not inhibited by monomeric glycerol phosphate, a finding indicating the participation of the polyglycerol phosphate (PGP) backbone of LTA in the reaction. Following interaction with PGP, MBP inhibited the agglutination of LTA-sensitized erythrocytes by induction of antibodies to LTA, directed against the PGP antigenic determinant. The amplification of the humoral immune response to the insoluble complex of LTA and MBP was of particular interest in view of the lack of immunogenicity of either LTA or MBP alone.
A组链球菌脂磷壁酸（LTA）是一种与脂肪酸相连的聚甘油磷酸酯，它与从牛脑中分离出的带正电荷的髓鞘碱性蛋白（MBP）在琼脂凝胶中形成沉淀线。LTA-MBP复合物是由脱酰基磷壁酸形成的，并且不受单体甘油磷酸的抑制，这一发现表明LTA的聚甘油磷酸（PGP）主链参与了该反应。与PGP相互作用后，MBP通过诱导针对PGP抗原决定簇的抗LTA抗体，抑制了LTA致敏红细胞的凝集。鉴于单独的LTA或MBP均缺乏免疫原性，对LTA和MBP不溶性复合物的体液免疫反应的增强尤其令人感兴趣。
