纯化且与载体复合的链球菌脂磷壁酸的免疫原性
Immunogenicity of a purified and carrier-complexed streptococcal lipoteichoic acid.
作者信息
Fiedel B A, Jackson R W
出版信息
Infect Immun. 1976 Jun;13(6):1585-90. doi: 10.1128/iai.13.6.1585-1590.1976.
Abstract
Solublie teichoic acid could not stimulate the formation of antibodies either as an aqueous solution or in an emulsion with Freund incomplete adjuvant. However, when given as precipitates with methylated bovine serum albumin, it stimulated strong anti-teichoic acid responses. High levels of anti-teichoic acid antibodies usually resulted in allergic symptoms upon secondary challenge either with immunogenic teichoic acid-methylated bovine albumin complexes or with non-immunogenic soluble teichoic acid. These symptoms suggested anaphylatic shock, but probably also included the formation of complement-consuming immune complexes.
摘要
可溶性磷壁酸无论是作为水溶液还是与弗氏不完全佐剂形成乳剂，都不能刺激抗体的形成。然而，当与甲基化牛血清白蛋白形成沉淀物给药时，它能刺激产生强烈的抗磷壁酸反应。高水平的抗磷壁酸抗体通常会在再次受到免疫原性磷壁酸 - 甲基化牛白蛋白复合物或非免疫原性可溶性磷壁酸攻击时引发过敏症状。这些症状提示为过敏性休克，但可能也包括补体消耗性免疫复合物的形成。
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