Department of Quality Assurance, Indo Soviet Friendship (ISF), College of Pharmacy, Moga, 142001, Punjab, India.
Department of Pharmaceutical Technology, MIET, Meerut, 250005, U.P., India.
Curr Pharm Biotechnol. 2024;25(3):285-300. doi: 10.2174/1389201024666230718114606.
Herbs have been used as sustenance and medicine for a very long time, often in conjunction with other prescribed medications. Even though they are thought to be natural and secure, many of these herbs can interact with other medications and cause potentially dangerous adverse effects or decrease the benefits of the medication. The complex and diverse pharmacological functions carried out by the active ingredients in herbs unavoidably alter the pharmacokinetics of chemical drugs when administered in vivo. Drug transporter expression has a direct impact on how medications are absorbed, distributed, metabolized, and excreted in living organisms. Changes in substrate pharmacokinetics can affect the effectiveness and toxicity of a drug when the active ingredients of a herb inhibit or stimulate the expression of transporters. By reviewing published clinical and preclinical studies, this review aims to raise awareness of herbdrug interactions and discuss their evidence-based mechanisms and clinical consequences. More clinical information on herb-drug interactions is required to make choices regarding patient safety as the incidence and severity of herb-drug interactions are rising due to an increase in the use of herbal preparations globally.This review seeks to increase understanding of herb-drug interactions and explore their evidence-based mechanisms and clinical implications by reviewing published clinical and preclinical studies. The incidence and severity of herb-drug interactions are on the rise due to an increase in the use of herbal preparations worldwide, necessitating the need for more clinical data on these interactions in order to make decisions regarding patient safety. Healthcare workers and patients will become more alert to potential interactions as their knowledge of pharmacokinetic herb-drug interactions grows. The study's objective is to raise readers' awareness of possible interactions between herbal supplements and prescription medications who regularly take them.
草药作为营养和药物已经使用了很长时间，通常与其他规定的药物一起使用。尽管它们被认为是天然和安全的，但许多这些草药可以与其他药物相互作用，并可能导致潜在的危险不良反应或降低药物的疗效。草药中活性成分执行的复杂多样的药理学功能不可避免地改变了体内化学药物的药代动力学。药物转运蛋白的表达直接影响药物在生物体内的吸收、分布、代谢和排泄方式。当草药的活性成分抑制或刺激转运体的表达时，底物药代动力学的变化会影响药物的疗效和毒性。通过回顾已发表的临床和临床前研究，本综述旨在提高对草药-药物相互作用的认识，并讨论其基于证据的机制和临床后果。由于全球范围内草药制剂的使用增加，草药-药物相互作用的发生率和严重程度正在上升，因此需要更多关于这些相互作用的临床信息，以便在患者安全性方面做出选择。
本综述通过回顾已发表的临床和临床前研究，旨在提高对草药-药物相互作用的认识，并探讨其基于证据的机制和临床意义。由于全球范围内草药制剂的使用增加，草药-药物相互作用的发生率和严重程度正在上升，因此需要更多关于这些相互作用的临床数据，以便在患者安全性方面做出决策。随着人们对药代动力学草药-药物相互作用的认识不断提高，医护人员和患者将更加警惕潜在的相互作用。本研究的目的是提高读者对经常服用草药补充剂和处方药的患者可能发生的相互作用的认识。
