Crusio W E, Genthner-Grimm G, Schwegler H
J Neurogenet. 1986 Jul;3(4):203-14. doi: 10.3109/01677068609106850.
This report analyses the genetic underpinnings of the proportions of the hippocampal terminal fields in the mouse at the midseptotemporal level. We used 5 inbred strains and all possible F1 crosses between them (diallel cross). Broad heritabilities ranged from 11 to 53%. Additive genetic variation was present for all phenotypes analyzed. Directional dominance was found for the relative size of the suprapyramidal mossy fiber terminal field only. For the stratum lacunosum-moleculare, ambidirectional dominance emerged. These findings suggest that, in evolutionary history, directional selection has operated for a proportionally large suprapyramidal terminal field. For all other hippocampal variables (viz. the relative sizes for the strata oriens, pyramidale, radiatum, lacunosum-moleculare, CA4, intra- and infrapyramidal mossy fiber terminal field and the absolute size of the regio inferior) past stabilizing selection was inferred.
本报告分析了小鼠中隔颞叶水平海马终末场比例的遗传基础。我们使用了5个近交系及其之间所有可能的F1杂交组合（双列杂交）。广义遗传力范围为11%至53%。所分析的所有表型均存在加性遗传变异。仅在锥体上苔藓纤维终末场的相对大小方面发现了定向显性。对于腔隙分子层，出现了双向显性。这些发现表明，在进化史上，定向选择作用于比例较大的锥体上终末场。对于所有其他海马变量（即海马各层、CA4、锥体内外苔藓纤维终末场的相对大小以及下区的绝对大小），推断过去存在稳定选择。
