口服PROTAC药物的探索：评估筛选流程的弱点
The Quest for Oral PROTAC drugs: Evaluating the Weaknesses of the Screening Pipeline.
作者信息
Apprato Giulia, Ermondi Giuseppe, Caron Giulia
机构信息
Molecular Biotechnology and Health Sciences Department, University of Torino, Piazza Nizza 44, 10124 Torino, Italy.
出版信息
ACS Med Chem Lett. 2023 Jul 3;14(7):879-883. doi: 10.1021/acsmedchemlett.3c00231. eCollection 2023 Jul 13.
Abstract
A targeted bibliographic search exposed the deficiencies within existing PROTAC preclinical pipelines, including missing, poor-quality data and technical limitations in the experimental assays. Several recommendations are proposed to improve the efficiency of preclinical platforms for PROTACs.
摘要
一项有针对性的文献检索揭示了现有PROTAC临床前研发流程中的缺陷，包括数据缺失、质量不佳以及实验分析中的技术局限性。本文提出了若干建议，以提高PROTAC临床前平台的效率。
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