Shabani Azadeh, Abiri Amene, Ghalandarpoor-Attar Seyedeh Noushin, Hadizadeh Alireza, Ghalandarpoor-Attar Seyedeh Mojgan
Department of Obstetrics and Gynecology, Shahid Taleghani Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Arash Women's Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Family Reprod Health. 2022 Dec;16(4):290-295. doi: 10.18502/jfrh.v16i4.11360.
This descriptive-analytic cross-sectional study aimed to figure out whether maternal serum vitamin D concentration correlates with cervical length measurement in mid-gestation or not.
During Jun-Jan 2021, 213 pregnant women at 18-22 weeks of gestation were investigated. First, demographic features were obtained then, maternal serum vitamin D concentration was measured by enzyme-linked immunoassay and cervical length was measured via transvaginal sonography according to fetal maternal foundation guideline and appropriate statistical test was used to analyze the correlation between maternal vitamin D level and cervical length in mid-pregnancy.
It was shown that 29.6% and 25.4% of participants had vitamin D deficiency and insufficiency, respectively. Spearman's test found no significant correlation between maternal vitamin D level and cervical length in mid-pregnancy. Moreover, cervical length and maternal vitamin D level had no association with maternal BMI.
Although maternal vitamin D level and its sufficiency status was not associated with cervical length in mid-pregnancy, as a trend toward decreased maternal serum vitamin D level by advancing gestational age was observed. It may be concluded that it is prolonged vitamin D deficiency during gestation that may lead to cervical length shortening and subsequent preterm delivery later in gestation.
本描述性分析横断面研究旨在确定孕中期孕妇血清维生素D浓度与宫颈长度测量值是否相关。
在2021年6月至次年1月期间，对213名妊娠18 - 22周的孕妇进行了调查。首先获取人口统计学特征，然后采用酶联免疫吸附测定法测量孕妇血清维生素D浓度，并根据胎儿 - 母亲基础指南经阴道超声测量宫颈长度，使用适当的统计检验分析孕中期孕妇维生素D水平与宫颈长度之间的相关性。
结果显示，分别有29.6%和25.4%的参与者存在维生素D缺乏和不足。Spearman检验发现孕中期孕妇维生素D水平与宫颈长度之间无显著相关性。此外，宫颈长度和孕妇维生素D水平与孕妇BMI无关。
尽管孕中期孕妇维生素D水平及其充足状态与宫颈长度无关，但观察到随着孕周增加孕妇血清维生素D水平有下降趋势。可以得出结论，妊娠期维生素D缺乏持续时间延长可能导致宫颈长度缩短及随后妊娠后期的早产。
