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梗死相关动脉存在大量血栓的患者的双重保护——一项单中心回顾性研究

Double protection in patients with a massive thrombus in the infarct-related artery - a single-center retrospective study.

作者信息

Chodór Piotr, Honisz Grzegorz, Wilczek Krzysztof, Świerad Marcin, Chodór-Rozwadowska Karolina, Kalarus Zbigniew

机构信息

Silesian Center for Heart Diseases, Department of Cardiology, Congenital Heart Diseases and Electrotherapy, Medical University of Silesia, Zabrze, Poland.

Silesian Center for Heart Diseases, 3 Department of Cardiology, Medical University of Silesia, Zabrze, Poland.

出版信息

Postepy Kardiol Interwencyjnej. 2023 Jun;19(2):127-134. doi: 10.5114/aic.2023.129211. Epub 2023 Jun 30.

Abstract

INTRODUCTION

ST-segment elevation myocardial infarction (STEMI) is associated with thrombus formation on a ruptured or ulcerated atherosclerotic plaque. The consequences of a massive thrombus (MT) may include lack of reperfusion, extensive myocardial infarction (MI) and its complications. Although there are various treatment options for patients with coronary thrombi, double protection (DP) - manual thrombectomy (MTH) with a distal protection device (DPD) - has not been tested yet.

AIM

To present DP outcomes in the treatment of patients with STEMI and MT patients.

MATERIAL AND METHODS

Fourteen patients with STEMI and MT were included in the study. Those patients underwent primary percutaneous coronary intervention (PPCI) with DP.

RESULTS

Inferior MI was found in 12 (85.8%) patients. Stents were implanted in 13 (92.8%) patients. Thrombolysis In Myocardial Infarction (TIMI) Thrombus Grade 5 was present in 11 (78.6%) patients and Grade 4 in 3 (21.4%) patients. The median thrombus length was 39.1 mm. Complete reperfusion (TIMI flow 3) was observed in 11 (78.6%) patients and TIMI flow 2 in 3 (21.4%) patients. Myocardial Blush Grade (MBG) was used in patients with TIMI flow 3 and Grade 3 was found in 5 (35.7%) patients. Resolution in ST-segment elevation > 50% was obtained in 13 (92.8%) patients. No myocardial rupture, stroke, or death occurred during hospitalization.

CONCLUSIONS

DP in MT patients is a safe and feasible procedure. However, further observations and studies are needed to assess the efficacy of this method.

摘要

引言

ST段抬高型心肌梗死(STEMI)与破裂或溃疡的动脉粥样硬化斑块上形成血栓有关。大量血栓(MT)的后果可能包括再灌注失败、广泛心肌梗死(MI)及其并发症。尽管对于冠状动脉血栓患者有多种治疗选择,但双重保护(DP)——使用远端保护装置(DPD)进行手动血栓切除术(MTH)——尚未经过测试。

目的

介绍DP治疗STEMI和MT患者的结果。

材料与方法

14例STEMI和MT患者纳入本研究。这些患者接受了DP下的直接经皮冠状动脉介入治疗(PPCI)。

结果

12例(85.8%)患者为下壁心肌梗死。13例(92.8%)患者植入了支架。心肌梗死溶栓(TIMI)血栓分级5级的有11例(78.6%),4级的有3例(21.4%)。血栓中位数长度为39.1毫米。11例(78.6%)患者观察到完全再灌注(TIMI血流3级),3例(21.4%)患者为TIMI血流2级。TIMI血流3级的患者采用心肌 blush分级(MBG),5例(35.7%)患者为3级。13例(92.8%)患者ST段抬高降低>50%。住院期间未发生心肌破裂、中风或死亡。

结论

MT患者的DP是一种安全可行的手术。然而,需要进一步观察和研究以评估该方法的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/189f/10351081/e559c2f5d5d1/PWKI-19-51021-g001.jpg

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