Department of Surgery and Radiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Department of Biochemistry, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Vet Med Sci. 2023 Sep;9(5):2070-2077. doi: 10.1002/vms3.1198. Epub 2023 Jul 19.
Minerals play vital roles in physiologic processes. Calcium, phosphorus and magnesium are common minerals. Secretion, absorption and homeostasis of these minerals are affected by associations between the active vitamin D and parathyroid hormone (PTH).
The aim of this study was to assess concentrations of vitamin D, PTH and minerals, such as calcium, phosphorus and magnesium in horse sera, as well as associations of these values with lameness in horses. In the references, the reasons for lameness can be deficiency and imbalance of minerals, and clinical observations also confirm this and there is still not enough information regarding the relationship between mineral imbalance and lameness of horses. The prominent forms of lameness include navicular syndrome, back pain, splints, ring bone, side bone, non-infectious arthritis and bucked shins. Deficiency and inadequacy of calcium, phosphorous and magnesium have been regarded as predisposing and aggravating factors of the aforementioned diseases.
This cross-sectional study was carried out on 60 horses, including 30 lame and 30 healthy adult horses, summer to fall 2021. Levels of calcium, phosphorus, magnesium, vitamin D and PTH were assessed in sera using automatic analyser, atomic absorption spectroscopy and commercially available kits.
The average level of calcium was higher healthy horses than lame horses in the two seasons (p < 0.001). The average level of inorganic phosphorus in horses was higher in summer than autumn (p < 0.001). The mean magnesium concentration in healthy horses was greater than lame horses in the two seasons (p < 0.01). In this study, the mean PTH concentration in healthy horses was lower in fall than summer (p < 0.05).
The low average levels of calcium and magnesium in lame horses in the two seasons indicate critical roles of calcium and magnesium in the normal function of the horse musculoskeletal system as well as prevention of lameness.
矿物质在生理过程中起着至关重要的作用。钙、磷和镁是常见的矿物质。这些矿物质的分泌、吸收和动态平衡受到活性维生素 D 和甲状旁腺激素（PTH）之间的关联影响。
本研究旨在评估马血清中的维生素 D、PTH 和矿物质（如钙、磷和镁）的浓度，并评估这些值与马跛行之间的关联。在参考文献中，跛行的原因可能是矿物质的缺乏和失衡，临床观察也证实了这一点，而且关于矿物质失衡与马跛行之间的关系还没有足够的信息。突出的跛行形式包括蹄叶炎综合征、背痛、夹板、环形骨、侧骨、非传染性关节炎和胫骨骨裂。钙、磷和镁的缺乏和不足被认为是上述疾病的诱发和加重因素。
这项横断面研究于 2021 年夏季至秋季对 60 匹马进行了研究，包括 30 匹跛行和 30 匹健康成年马。使用自动分析仪、原子吸收光谱法和市售试剂盒评估血清中的钙、磷、镁、维生素 D 和 PTH 水平。
在两个季节中，健康马的血清钙平均水平高于跛行马（p<0.001）。马的血清无机磷平均水平在夏季高于秋季（p<0.001）。在两个季节中，健康马的血清镁平均浓度均高于跛行马（p<0.01）。在本研究中，健康马的血清 PTH 平均浓度在秋季低于夏季（p<0.05）。
两个季节中跛行马的血清钙和镁平均水平较低，表明钙和镁在马肌肉骨骼系统的正常功能以及预防跛行方面发挥着关键作用。
