Pozza Megan E, Kaewsakhorn Thattawan, Trinarong Chumnan, Inpanbutr Nongnuch, Toribio Ramiro E
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp Street, Columbus, OH 43210, USA.
Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
Vet J. 2014 Mar;199(3):451-6. doi: 10.1016/j.tvjl.2014.01.002. Epub 2014 Jan 11.
Vitamin D is essential in calcium and phosphorus regulation, bone physiology, cell proliferation and epithelial integrity. Literature on vitamin D in growing horses is sparse, and the effect of age on vitamin D has not been evaluated in equids in the United States or in tropical countries. The goal of this study was to determine if there was an effect of age on serum 25(OH)D3 concentrations in equids in the US (Ohio/Kentucky) and Thailand (Chiang Rai and Kanchanaburi) during the same time of the year. Blood samples were collected from healthy ponies (n=21) and Thoroughbred foals (n=13), yearlings (n=10), and horses (n=20) in Thailand and from Thoroughbred foals (n=10) and horses (n=17) in the US. Serum concentrations of 25(OH)D3, calcium and phosphorus were measured. In both countries, serum 25(OH)D3 concentrations were lower in foals than in yearlings and adult horses. Serum 25(OH)D3 concentrations were higher in horses than in ponies in Thailand, but were not different between horses from either country. Calcium concentrations were not different between groups or location. In both countries, phosphorus concentrations were higher in foals than in older groups; however, were not different between ponies and horses. This study shows that independent of geography there are age-related differences in 25(OH)D3 concentrations in horses and further confirms that 25(OH)D3 concentrations are lower in horses compared to other species. The information will serve as the basis for future clinical studies and to help understand better the pathophysiology of equine disorders associated with calcium and phosphorus dysregulation.
维生素D在钙和磷的调节、骨骼生理、细胞增殖以及上皮完整性方面至关重要。关于生长马匹维生素D的文献稀少，在美国或热带国家的马属动物中，年龄对维生素D的影响尚未得到评估。本研究的目的是确定在美国（俄亥俄州/肯塔基州）和泰国（清莱府和北碧府）同一时期，年龄对马属动物血清25(OH)D3浓度是否有影响。从泰国的健康矮种马（n = 21）、纯种马驹（n = 13）、一岁马（n = 10）和成年马（n = 20）以及美国的纯种马驹（n = 10）和成年马（n = 17）采集血样。检测血清中25(OH)D3、钙和磷的浓度。在两个国家，马驹的血清25(OH)D3浓度均低于一岁马和成年马。在泰国，成年马的血清25(OH)D3浓度高于矮种马，但两个国家的成年马之间无差异。各年龄组或不同地点之间的钙浓度无差异。在两个国家，马驹的磷浓度均高于年龄较大的组；然而，矮种马和成年马之间无差异。本研究表明，与地理位置无关，马匹的25(OH)D3浓度存在年龄相关差异，并进一步证实与其他物种相比，马匹的25(OH)D3浓度较低。该信息将作为未来临床研究的基础，并有助于更好地理解与钙和磷调节异常相关的马属动物疾病的病理生理学。
