Department of Epidemiology, University of Washington, Seattle, Washington.
Departments of Epidemiology and Medicine, University of North Carolina Chapel Hill, Chapel Hill, North Carolina.
Cancer Epidemiol Biomarkers Prev. 2023 Oct 2;32(10):1470-1473. doi: 10.1158/1055-9965.EPI-23-0305.
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related somatic mutation associated with incident hematologic cancer. Environmental stressors which, like air pollution, generate oxidative stress at the cellular level, may induce somatic mutations and some mutations may provide a selection advantage for persistence and expansion of specific clones.
We used data from the Multi-Ethnic Study of Atherosclerosis (MESA) N = 4,379 and the Women's Health Initiative (WHI) N = 7,701 to estimate cross-sectional associations between annual average air pollution concentrations at participant address the year before blood draw using validated spatiotemporal models. We used covariate-adjusted logistic regression to estimate risk of CHIP per interquartile range increases in particulate matter (PM2.5; 4 μg/m3) and nitrogen dioxide (NO2; 10 ppb) as ORs (95% confidence intervals).
Prevalence of CHIP at blood draw (variant allele fraction > 2%) was 4.4% and 8.7% in MESA and WHI, respectively. The most common CHIP driver mutation was in DNMT3A. Neither pollutant was associated with CHIP: ORMESA PM2.5 = 1.00 (0.68-1.45), ORMESA NO2 = 1.05 (0.69-1.61), ORWHI PM2.5 = 0.97 (0.86-1.09), ORWHI NO2 = 0.98 (0.88-1.10); or with DNMT3A-driven CHIP.
We did not find evidence that air pollution contributes to CHIP prevalence in two large observational cohorts.
This is the first study to estimate associations between air pollution and CHIP.
不确定潜能的克隆性造血（CHIP）是一种与血液系统恶性肿瘤相关的年龄相关的体细胞突变。环境应激源，如空气污染，会在细胞水平上产生氧化应激，可能会诱导体细胞突变，而某些突变可能为特定克隆的持续存在和扩张提供选择优势。
我们使用来自多民族动脉粥样硬化研究（MESA）N = 4379 例和妇女健康倡议（WHI）N = 7701 例的数据，使用经过验证的时空模型估计参与者血液采集前一年地址的年度平均空气污染浓度与 CHIP 之间的横断面关联。我们使用协变量调整的逻辑回归估计每四分位间距增加颗粒物（PM2.5；4μg/m3）和二氧化氮（NO2；10ppb）的 CHIP 风险比（95%置信区间）。
血液采集时 CHIP 的患病率（变异等位基因分数>2%）分别为 MESA 和 WHI 的 4.4%和 8.7%。最常见的 CHIP 驱动突变发生在 DNMT3A 中。两种污染物均与 CHIP 无关：ORMESA PM2.5=1.00（0.68-1.45），ORMESA NO2=1.05（0.69-1.61），ORWHI PM2.5=0.97（0.86-1.09），ORWHI NO2=0.98（0.88-1.10）；或与 DNMT3A 驱动的 CHIP 无关。
我们没有发现证据表明空气污染会导致两个大型观察队列中 CHIP 的患病率增加。
这是第一项估计空气污染与 CHIP 之间关联的研究。
