The Affiliated Hospital of Yunnan University, School of Ecology and Environmental Science, Yunnan University, Kunming, 650032, China.
Guangxi Key Laboratory of Green Processing of Sugar Resources, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Mikrochim Acta. 2023 Jul 19;190(8):307. doi: 10.1007/s00604-023-05881-1.
Porous highly boron-doped BCN (p-BCN) was produced by using a boron cluster salt (closo-[BH]) as the boron-based precursor and SiO as a hard template. The synthesized p-BCN was used in an electrochemical sensor for the ultrasensitive and highly selective detection of morphine (MOP). The optimal conditions for MOP detection were determined by optimizing the experimental conditions. Under these optimal conditions, the p-BCN-based sensor exhibited excellent MOP detection performance (working potential of 0.2 V). Specifically, it showed a detection range of 0.05 to 200 μM and a detection limit of 17.8 nM. Notably, the p-BCN-based electrochemical sensor was successfully applied to the determination of MOP in human blood, and the results showed satisfactory recovery and accuracy. Therefore, this sensor can be used as an effective platform for the detection of MOP in human blood samples.
多孔高掺硼 BCN（p-BCN）是通过使用硼簇盐（closo-[BH]) 作为硼源前体和 SiO 作为硬模板制备得到的。所合成的 p-BCN 被用于电化学传感器中，以超灵敏和高选择性地检测吗啡（MOP）。通过优化实验条件，确定了 MOP 检测的最佳条件。在这些最佳条件下，基于 p-BCN 的传感器表现出优异的 MOP 检测性能（工作电位为 0.2 V）。具体而言，它显示出 0.05 至 200 μM 的检测范围和 17.8 nM 的检测限。值得注意的是，基于 p-BCN 的电化学传感器已成功应用于人血中 MOP 的测定，结果显示出令人满意的回收率和准确性。因此，该传感器可用作检测人血样中 MOP 的有效平台。
