Department of Gastroenterology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China.
Department of Pharmacy, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China.
Clin Transl Gastroenterol. 2023 Nov 1;14(11):e00624. doi: 10.14309/ctg.0000000000000624.
The aim of this study was to explore the clinical characteristics and related factors of centrally mediated abdominal pain syndrome (CAPS).
Our study included 73 patients with CAPS and 132 age-matched and gender-matched healthy controls. The general information of the participants was collected, and the questionnaires were completed including the 7-item Generalized Anxiety Disorder Scale, 9-item Patient Health Questionnaire, Hamilton Anxiety Scale, Hamilton Depression Scale Pittsburgh Sleep Quality Index, Visual Analog Scale, and Short-Form 36. Univariate and forward stepwise regression analyses were performed to explore the influencing factors of CAPS.
Nonexercise (adjusted odds ration [AOR] 4.53; confidence interval [CI] 1.602-12.809), mild-to-moderate depression (AOR 7.931; CI 3.236-19.438), married status (AOR 3.656; CI 1.317-10.418), and drinking coffee (AOR 0.199; CI 0.051-0.775) were found to be related with centrally mediated abdominal syndrome. The Hamilton Anxiety Scale score (7-13) was significantly related to moderate-to-severe abdominal pain (AOR 7.043; CI 1.319-37.593). Higher Hamilton Depression Scale score was related to lower mental component scale score (β = -0.726, P < 0.01) and physical component scale score (β = -0.706, P < 0.01).
Depression, married status, and nonexercise were the independent risk factors of CAPS. Conversely, coffee intake was an independent protective factor of CAPS. Anxiety was related to the severity of abdominal pain, while depression was related to low health-related quality of life.
本研究旨在探讨中枢介导性腹痛综合征（CAPS）的临床特征及相关因素。
纳入 73 例 CAPS 患者和 132 例年龄、性别匹配的健康对照者，收集参与者一般资料，采用 7 项广泛性焦虑障碍量表、9 项患者健康问卷、汉密尔顿焦虑量表、汉密尔顿抑郁量表、匹兹堡睡眠质量指数、视觉模拟评分、SF-36 量表进行问卷调查。采用单因素和逐步向前回归分析探讨 CAPS 的影响因素。
非运动（调整后优势比 [OR] 4.53，95%置信区间 [CI] 1.602-12.809）、轻-中度抑郁（OR 7.931，95%CI 3.236-19.438）、已婚状态（OR 3.656，95%CI 1.317-10.418）和喝咖啡（OR 0.199，95%CI 0.051-0.775）与中枢介导性腹痛综合征相关。汉密尔顿焦虑量表评分（7-13 分）与中-重度腹痛显著相关（OR 7.043，95%CI 1.319-37.593）。汉密尔顿抑郁量表评分越高，心理成分量表评分越低（β=-0.726，P<0.01），生理成分量表评分越低（β=-0.706，P<0.01）。
抑郁、已婚状态和非运动是 CAPS 的独立危险因素，相反，咖啡摄入是 CAPS 的独立保护因素。焦虑与腹痛严重程度相关，抑郁与健康相关生活质量低相关。
