Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Neurol Neurosurg. 2023 Sep;232:107846. doi: 10.1016/j.clineuro.2023.107846. Epub 2023 Jun 23.
Several studies demonstrated the association between tobacco smoking and higher risk and increased progression of multiple sclerosis (MS). Data about the effect of smoking during the recovery from MS attacks is limited. Furthermore, different types of tobacco exposures such as water pipe and passive smoking are not well assessed separately. So this study evaluated the effect of different types of smokes, cigarette and water pipe as well as passive smoking on the function recovery of relapsing-remitting MS (RRMS) attacks METHODS: This cohort study evaluated the adult patients with RRMS and Expanded Disability Status Scale (EDSS) < 5 in the attack phase. Patients were divided into two groups: smokers and non-smokers. The smokers included those who use cigarette, water pipe as well as passive smokers as subgroups for more analyses later. EDSS was monitored after relapse and two months after relapse. Change of EDSS considered as the criteria for functional recovery. The correlation between the amount of consumption and disability level was assessed among smokers by Pearson's correlation test. While, the difference of EDSS between smoker and non-smoker were assessed by Independent samples T-test.
142 patients were evaluated. 79 (55.6%) were smokers (43% male) while 63 (44.4%) were non-smokers (36.5% male). There was a statistically significant difference in change of EDSS between smoker and non-smoker groups, which change of EDSS was higher in non-smoker (-2.62 ± 0.90 non-smoker vs. -1.75 ± 0.76 smoker, P < 0.001). Also, only there was a significantly lesser decline in EDSS after two months in the cigarette smokers in subgroups analyses (P < 0.001). A correlation analysis revealed a significant positive correlation between the number per day of cigarette smoking and EDSS after relapse (r = 0.3, P = 0.03) and a significant positive correlation between minutes per month of smoking of water pipe and EDSS two months after relapse (r = 0.6, P > 0.001).
Tobacco smoking especially cigarette smoking is associated with a negative effect on recovery from the attack in patients with RRMS.
多项研究表明，吸烟与多发性硬化症（MS）风险增加和病情进展有关。关于吸烟对 MS 发作后恢复的影响的数据有限。此外，水烟和被动吸烟等不同类型的烟草暴露也没有得到很好的单独评估。因此，本研究评估了不同类型的烟雾、香烟和水烟以及被动吸烟对复发性缓解型多发性硬化症（RRMS）发作后功能恢复的影响。
这项队列研究评估了发作期 EDSS<5 的成年 RRMS 患者。患者分为两组：吸烟者和非吸烟者。吸烟者包括使用香烟、水烟和被动吸烟者的人群，以便进行进一步分析。在复发后和复发后两个月监测 EDSS。EDSS 的变化被认为是功能恢复的标准。通过 Pearson 相关检验评估吸烟者中消耗量与残疾程度之间的相关性。而通过独立样本 T 检验评估吸烟者和非吸烟者之间 EDSS 的差异。
共评估了 142 名患者。79 名（55.6%）为吸烟者（43%为男性），63 名（44.4%）为非吸烟者（36.5%为男性）。吸烟者和非吸烟者之间 EDSS 的变化存在统计学显著差异，非吸烟者的 EDSS 变化更高（-2.62±0.90 非吸烟者与-1.75±0.76 吸烟者，P<0.001）。此外，仅在亚组分析中，香烟吸烟者在两个月后 EDSS 的下降幅度显著较小（P<0.001）。相关性分析显示，吸烟量与复发后 EDSS 之间存在显著正相关（r=0.3，P=0.03），水烟吸烟分钟数与复发后两个月 EDSS 之间存在显著正相关（r=0.6，P>0.001）。
吸烟，尤其是香烟吸烟，与 RRMS 患者发作后恢复的负面影响有关。
