James L J, Parfitt R T
J Med Chem. 1986 Sep;29(9):1783-5. doi: 10.1021/jm00159a038.
The synthesis of four 3-substituted 6-tert-butyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines is described. Derivatives with N-Me or N-phenethyl substituents do not differ significantly in their antinociceptive properties from compounds bearing 6-H or 6-Me; however, they are less active than 6-Ph analogues.
本文描述了四种3-取代的6-叔丁基-1,2,3,4,5,6-六氢-2,6-亚甲基-3-苯并氮杂卓的合成。具有N-甲基或N-苯乙基取代基的衍生物在其抗伤害感受特性方面与带有6-H或6-甲基的化合物没有显著差异；然而，它们的活性低于6-苯基类似物。
