1,2,3,4,5,6-六氢-1,6-亚甲基-2-苯并氮杂卓的合成及药理性质
Synthesis and pharmacological properties of 1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocines.
作者信息
Mazzocchi P H, Stahly B C
出版信息
J Med Chem. 1981 Apr;24(4):457-62. doi: 10.1021/jm00136a016.
PMID:7265131
Abstract
1,2,3,4,5,6-Hexahydro-1,6-methano-2-benzazocine, 2'-methoxy-1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocine, and N-alkyl derivatives of 2'-hydroxy-1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocine have been synthesized in order to evaluate their analgesic activities. These compounds show only slight antinociceptive activities in the mouse hot-plate assay.
摘要
为评估其镇痛活性，已合成了1,2,3,4,5,6-六氢-1,6-亚甲基-2-苯并氮杂卓、2'-甲氧基-1,2,3,4,5,6-六氢-1,6-亚甲基-2-苯并氮杂卓以及2'-羟基-1,2,3,4,5,6-六氢-1,6-亚甲基-2-苯并氮杂卓的N-烷基衍生物。这些化合物在小鼠热板试验中仅表现出轻微的抗伤害感受活性。
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