• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用纳武单抗成功治疗转移性食管鳞状细胞癌所致恶性心包炎

Successful Management of Malignant Pericarditis Using Nivolumab for Metastatic Esophageal Squamous Cell Carcinoma.

作者信息

Uneno Yu, Nomura Motoo, Hosokai Taisuke, Kurakake Yoshinosuke, Fuki Masayuki, Shiomi Hiroki, Takeuchi Yasuhide, Tamaoki Masashi, Yokoyama Akira, Katada Chikatoshi, Muto Manabu

机构信息

Department of Clinical Oncology, Kyoto University Hospital, Japan.

Department of Cardiovascular Medicine, Kyoto University Hospital, Japan.

出版信息

Intern Med. 2024 Mar 1;63(5):677-680. doi: 10.2169/internalmedicine.2041-23. Epub 2023 Jul 19.

DOI:10.2169/internalmedicine.2041-23
PMID:37468243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10982021/
Abstract

Esophageal cancer is a malignant disease with a poor prognosis and is one of the most common causes of cardiac metastasis. Malignant pericarditis may cause the repetitive accumulation of pericardial effusion, which can occasionally pose a clinical challenge. We herein report a case of malignant pericarditis in a patient with metastatic esophageal squamous cell carcinoma with cardiac tamponade, which was successfully managed with single pericardial drainage and systemic nivolumab monotherapy. This is the first case report to suggest that systemic therapy with nivolumab is a promising option for the management of malignant pericarditis.

摘要

食管癌是一种预后较差的恶性疾病，是心脏转移最常见的原因之一。恶性心包炎可能导致心包积液反复积聚，偶尔会带来临床挑战。我们在此报告一例转移性食管鳞状细胞癌患者发生恶性心包炎并伴有心脏压塞，通过单次心包引流和全身使用纳武单抗单药治疗成功处理。这是首例提示纳武单抗全身治疗是恶性心包炎治疗的一种有前景选择的病例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6a4/10982021/5f9fe1d5a818/1349-7235-63-0677-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6a4/10982021/813b9ee3eb78/1349-7235-63-0677-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6a4/10982021/5f9fe1d5a818/1349-7235-63-0677-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6a4/10982021/813b9ee3eb78/1349-7235-63-0677-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6a4/10982021/5f9fe1d5a818/1349-7235-63-0677-g002.jpg

相似文献

1
Successful Management of Malignant Pericarditis Using Nivolumab for Metastatic Esophageal Squamous Cell Carcinoma.使用纳武单抗成功治疗转移性食管鳞状细胞癌所致恶性心包炎
Intern Med. 2024 Mar 1;63(5):677-680. doi: 10.2169/internalmedicine.2041-23. Epub 2023 Jul 19.
2
Cardiac tamponade and purulent pericarditis secondary to an oesophageal pericardial fistula as an initial presentation of squamous cell carcinoma of the oesophagus.食管心包瘘继发心脏压塞和脓性心包炎，作为食管鳞状细胞癌的初始表现。
BMJ Case Rep. 2019 Jul 17;12(7):e229634. doi: 10.1136/bcr-2019-229634.
3
Esophageal-pericardial fistula with purulent pericarditis secondary to esophageal carcinoma presenting with tamponade.食管癌继发食管心包瘘伴脓性心包炎并出现心脏压塞。
Ann Thorac Surg. 2003 Jan;75(1):288-9. doi: 10.1016/s0003-4975(02)04168-1.
4
[Two cases of cardiac tamponade, complicated by malignant, effusive pericarditis and treated by creating a pericardial peritoneal window].两例恶性渗出性心包炎并发心脏压塞并通过建立心包-腹膜窗口进行治疗的病例
Gan No Rinsho. 1989 Feb;35(3):393-6.
5
Pericarditis as the initial manifestation of malignant thymoma. Disappearance of pericardial effusion with corticosteroid therapy.心包炎作为恶性胸腺瘤的初始表现。皮质类固醇治疗使心包积液消失。
Chest. 1994 Jul;106(1):313-4. doi: 10.1378/chest.106.1.313.
6
Purulent Pericarditis as the First Manifestation of Esophageal Carcinoma.化脓性心包炎为食管癌的首发表现。
Port J Card Thorac Vasc Surg. 2024 May 13;31(1):59-62. doi: 10.48729/pjctvs.423.
7
[Malignant pericardial effusion after esophageal cancer surgery successfully treated by intrapericardial instillation of CDDP].[食管癌手术后恶性心包积液经心包内注射顺铂成功治疗]
Gan To Kagaku Ryoho. 1989 Jul;16(7):2433-6.
8
[A case of cardiac tamponade due to malignant pericarditis with lung adenocarcinoma, effectively treated with pericardial drainage and pemetrexed plus cisplatin chemotherapy].[1例因肺腺癌合并恶性心包炎导致的心包填塞，经心包引流及培美曲塞联合顺铂化疗有效治疗]
Nihon Ronen Igakkai Zasshi. 2015;52(4):421-4. doi: 10.3143/geriatrics.52.421.
9
Immune-mediated Pericarditis With Pericardial Tamponade During Nivolumab Therapy.免疫介导性心包炎伴心包填塞在纳武利尤单抗治疗期间。
J Immunother. 2018 Sep;41(7):329-331. doi: 10.1097/CJI.0000000000000217.
10
A case of cardiac tamponade following esophageal resection.一例食管切除术后心脏压塞病例。
J Anesth. 2005;19(3):249-51. doi: 10.1007/s00540-005-0326-0.

本文引用的文献

1
EpCAM expression in esophageal cancer and its correlation with immunotherapy of solitomab.EpCAM在食管癌中的表达及其与索立妥单抗免疫治疗的相关性。
J Thorac Dis. 2021 Apr;13(4):2404-2413. doi: 10.21037/jtd-21-442.
2
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.纳武利尤单抗对比化疗用于既往化疗后进展或不耐受的晚期食管鳞癌患者（ATTRACTION-3）：一项多中心、随机、开放标签、III 期临床研究。
Lancet Oncol. 2019 Nov;20(11):1506-1517. doi: 10.1016/S1470-2045(19)30626-6. Epub 2019 Sep 30.
3
Acute coronary syndrome as a possible immune-related adverse event in a lung cancer patient achieving a complete response to anti-PD-1 immune checkpoint antibody.
急性冠状动脉综合征作为一名对抗PD-1免疫检查点抗体获得完全缓解的肺癌患者可能出现的免疫相关不良事件。
Ann Oncol. 2017 Nov 1;28(11):2893-2895. doi: 10.1093/annonc/mdx326.
4
[A case of cardiac tamponade due to malignant pericarditis with lung adenocarcinoma, effectively treated with pericardial drainage and pemetrexed plus cisplatin chemotherapy].[1例因肺腺癌合并恶性心包炎导致的心包填塞，经心包引流及培美曲塞联合顺铂化疗有效治疗]
Nihon Ronen Igakkai Zasshi. 2015;52(4):421-4. doi: 10.3143/geriatrics.52.421.
5
2015 ESC Guidelines for the diagnosis and management of pericardial diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC)Endorsed by: The European Association for Cardio-Thoracic Surgery (EACTS).2015年欧洲心脏病学会（ESC）心包疾病诊断和管理指南：欧洲心脏病学会（ESC）心包疾病诊断和管理工作组 认可机构：欧洲心胸外科学会（EACTS）
Eur Heart J. 2015 Nov 7;36(42):2921-2964. doi: 10.1093/eurheartj/ehv318. Epub 2015 Aug 29.
6
Characteristics of neoplastic cardiac tamponade and prognosis after pericardiocentesis: a single-center study of 113 consecutive cancer patients.
Int J Clin Oncol. 2015 Oct;20(5):872-7. doi: 10.1007/s10147-015-0794-7. Epub 2015 Feb 6.
7
Malignant pericardial effusion.恶性心包积液
Cardiology. 2013;124(4):224-32. doi: 10.1159/000348559. Epub 2013 Apr 5.
8
Pericardiocentesis with cisplatin for malignant pericardial effusion and tamponade.心包穿刺术联合顺铂治疗恶性心包积液并心脏压塞。
World J Gastroenterol. 2010 Feb 14;16(6):740-4. doi: 10.3748/wjg.v16.i6.740.
9
[Recurrent metastatic pericarditis treated by chemotherapy].
Tunis Med. 2008 Nov;86(11):1027-8.
10
A randomised trial of intrapericardial bleomycin for malignant pericardial effusion with lung cancer (JCOG9811).一项关于心包内注射博来霉素治疗肺癌所致恶性心包积液的随机试验（JCOG9811）。
Br J Cancer. 2009 Feb 10;100(3):464-9. doi: 10.1038/sj.bjc.6604866. Epub 2009 Jan 20.