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静脉注射环磷酰胺成功治疗并以霉酚酸酯维持治疗的伴有胃肠道症状的多药耐药性IgA血管炎

Multidrug-resistant IgA Vasculitis with Gastrointestinal Symptoms Successfully Treated with Intravenous Cyclophosphamide and Maintained with Mycophenolate Mofetil.

作者信息

Miki Haruka, Tsuboi Hiroto, Kawashima Fumina, Sugita Toshiki, Nishiyama Taihei, Kuroda Yuki, Sawabe Tomonori, Uematsu Nana, Terasaki Mayu, Kitada Ayako, Honda Fumika, Ohyama Ayako, Yagishita Mizuki, Asashima Hiromitsu, Hagiwara Shinya, Kondo Yuya, Matsumoto Isao

机构信息

Department of Rheumatology, Institute of Medicine, University of Tsukuba, Japan.

出版信息

Intern Med. 2024 Mar 1;63(5):743-747. doi: 10.2169/internalmedicine.1990-23. Epub 2023 Jul 19.

DOI:10.2169/internalmedicine.1990-23
PMID:37468247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10982010/
Abstract

We present the case of a 17-year-old woman with IgA vasculitis (IgAV) who presented with relapsing gastrointestinal (GI) symptoms that were refractory to glucocorticoid and combination therapy with cyclosporine A, azathioprine or mycophenolate mofetil (MMF). The patient responded well to remission induction with intravenous cyclophosphamide (IVCY) and was successfully maintained with MMF. Remission induction with IVCY followed by maintenance therapy with MMF was effective in a patient with multidrug-resistant IgAV with GI lesions.

摘要

我们报告了一例17岁患有IgA血管炎（IgAV）的女性病例，该患者出现复发性胃肠道（GI）症状，对糖皮质激素以及环孢素A、硫唑嘌呤或霉酚酸酯（MMF）联合治疗均无效。患者对静脉注射环磷酰胺（IVCY）诱导缓解反应良好，并成功地用MMF维持治疗。对于一名患有伴有胃肠道病变的多药耐药性IgAV患者，IVCY诱导缓解后用MMF维持治疗是有效的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef3/10982010/046edfbb6f89/1349-7235-63-0743-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef3/10982010/1da3ede2ecc0/1349-7235-63-0743-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef3/10982010/e74f53bf77b2/1349-7235-63-0743-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef3/10982010/046edfbb6f89/1349-7235-63-0743-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef3/10982010/1da3ede2ecc0/1349-7235-63-0743-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef3/10982010/e74f53bf77b2/1349-7235-63-0743-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aef3/10982010/046edfbb6f89/1349-7235-63-0743-g003.jpg

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本文引用的文献

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ANCA-associated vasculitis.抗中性粒细胞胞浆抗体相关性血管炎。
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