Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Japan.
Intern Med. 2023 Oct 15;62(20):3063-3067. doi: 10.2169/internalmedicine.1788-23. Epub 2023 Jul 19.
Angioedema with eosinophilia (AE) is a rare disease of unknown etiology characterized by episodic (EAE) or nonepisodic AE (NEAE). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA-based vaccines function as immunogens and intrinsic adjuvants and have been shown to be safe in large-scale trials. However, the long-term adverse reactions, especially those related to eosinophilic complications, have not been fully clarified. We herein report a case of self-limited but severe NEAE that developed in a young woman one week after receiving the second BNT162b2 mRNA vaccine. The symptoms that impaired her activities of daily living, such as edema, gradually resolved with supportive care over 10 weeks without corticosteroid treatment.
血管性水肿伴嗜酸性粒细胞增多症（AE）是一种病因不明的罕见疾病，其特征为发作性（EAE）或非发作性 AE（NEAE）。基于严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）mRNA 的疫苗作为免疫原和内在佐剂发挥作用，并在大规模试验中被证明是安全的。然而，长期不良反应，特别是与嗜酸性粒细胞并发症相关的不良反应，尚未完全阐明。本文报告了一例年轻女性在接受第二剂 BNT162b2 mRNA 疫苗后一周发生的自限性但严重的 NEAE 病例。日常生活活动受限的症状（如水肿）在 10 周的支持性治疗下逐渐缓解，无需皮质类固醇治疗。
